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Table 4 Sorting of different methods according to the sensitivity and specificity criteria (128 proteins set)

From: Improved prediction of critical residues for protein function based on network and phylogenetic analyses

Method

Proportion of amino acids predicted

Error

Sen.

Spe.

Hssp

24%

0,41

72%

77%

Conseq

27%

0,44

71%

74%

Union set (10)

25%

0,50

61%

76%

Closeness

36%

0,56

64%

64%

Intersection set (9)

32%

0,58

60%

68%

Betweenness (2)

33%

0,58

58%

67%

2-connectivity (3)

37%

0,60

60%

64%

1/cluster (5)

49%

0,63

68%

51%

1/eccentricity

24%

0,64

44%

77%

Connectivity (4)

49%

0,65

65%

51%

  1. Results are obtained in average other the set of 128 proteins. Numbers are obtained by calculating the average as in Table 1.