From: A stepwise framework for the normalization of array CGH data
Array | Reference DNA | Sample DNA | Data type for normalization performance evaluation | Evaluation method |
---|---|---|---|---|
MM-1 to MM-4 | Male genomic | Male genomic | Self-self hybridizations | S.d. for each array |
H526-1 to H526-8 | H526 cell line | Male genomic | Replicate H526 cell line experiments | 1. Correlation coefficient for each pair of arrays 2. ICC 3. S.d. for each spot |
MF-1 and MF-2 | Female genomic | Male genomic | Single copy change | T-test |
T1 to T5 | Female genomic | Male/Female mixture (see Additional file 1) | Single copy loss with normal cell contamination | T-test |
T6 to T10 | Male genomic | Male/Female mixture (see Additional file 1) | Single copy gain with normal cell contamination | T-test |
X1 to X5 | Female DNA | cell lines containing varying numbers of X chromosomes (see Additional file 2) | varying levels of gene amplification and deletion for each of the X-chromosomal genes | T-test |