Figure 1
From: Multiple sequence alignment accuracy and evolutionary distance estimation
Possible optimal locations of intermediate sequences. Cartoon phylogenies indicating possible hypothesized optimal locations for the addition of an intermediate sequence (C) to improve the alignment of a pair of target sequences (A and B). The left column contains unrooted trees, the right column rooted trees. In the top row C is equidistant from A and B. In the bottom row, C is equidistant from A and the root of the tree.