Figure 1

Validation results of the MASK method using the virtual genetic network. (a) Part of the virtual genetic network shown in Ref. [21]. The regulation of gene G by gene C was employed to compare the MASK method and conventional kinetic model. (b) A log-log scatter plot of the R values of gene C and G. (c) The training data used in estimating the MASK model parameters. (d) The test data used for the validation of the MASK model. Applied to the same gene C expression time series, the MASK model calculated the time course of gene G as accurately as the original kinetic model. The model parameters were not changed.