Table 2 Summary of results for the simulated data. Numbers of genes declared significant (i.e., significantly differentially expressed) by different numbers of labs and the fixed and random effects meta-analyses in the simulation example. The False Discovery Rate (FDR) for the meta-analyses and each lab separately was controlled at 0.05. There were 21 Integration-Driven Discoveries (IDD's) and 4 Integration-Driven Revisions (IDR's).
| Â | Fixed Effects Model | Random Effects Model | ||
|---|---|---|---|---|
Num. of Labs Declaring | Number of Genes Declared | Number of Genes Declared | ||
Significance | Not Significant | Significant | Not Significant | Significant |
0 | 1152 | 51 | 1182 | 21 |
1 | 33 | 38 | 64 | 7 |
2 | 3 | 8 | 4 | 4 |
3 | 0 | 4 | 0 | 4 |
4 | 0 | 3 | 0 | 3 |
5 | 0 | 7 | 0 | 7 |
6 | 0 | 26 | 0 | 26 |
| Â | 1188 | 137 | 1250 | 72 |