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Table 5 Summary of results from the EAE example. Numbers of genes declared significantly differentially expressed by different numbers of experiments and the fixed and random effects meta-analyses in the observed data example. The False Discovery Rate (FDR) for the meta-analyses and each experiment separately was controlled at 0.05. There were 65 Integration-Driven Discoveries (IDD's) and 5518 Integration-Driven Revisions (IDR's). There were 32 IDR's that had been declared significantly differentially expressed by all seven experiments.

From: Combining Affymetrix microarray results

 

Fixed Effects Model

Random Effects Model

Number of Experiments Declaring

Number of Genes Declared

Number of Genes Declared

Significance

Not Significant

Significant

Not Significant

Significant

0

1792

301

2028

65

1

804

2265

1558

1511

2

749

1409

1869

289

3

625

1512

1662

475

4

328

1319

1084

563

5

152

908

617

443

6

54

464

254

264

7

8

85

32

61

 

4512

8263

9104

3671