Table 1 The twenty pairs of cancer types with the highest ratio of observed (O) to expected (E) number of associated genes. The O/E ratio and a 95% confidence interval (95%CI) are provided. Results are based on cancers mentioned in Online Mendelian Inheritance in Man (OMIM; http://www.ncbi.nlm.nih.gov/omim/) searched September 30, 2004.

Observed (O)

Expected (E)

cervix – larynx

2

0.16

12.6 ± 4.9

larynx – mouth

2

0.17

11.6 ± 4.8

larynx – uterus

2

0.25

7.9 ± 3.9

esophagus – stomach

21

2.80

7.5 ± 1.2

larynx – stomach

3

0.44

6.9 ± 3.0

bladder – esophagus

10

1.51

6.6 ± 1.6

larynx – myeloma

1

0.15

6.6 ± 5.1

larynx – esophagus

1

0.16

6.2 ± 4.9

cervix – esophagus

6

1.02

5.9 ± 1.9

bladder – cervix

8

1.47

5.4 ± 1.6

cervix – uterus

8

1.59

5.1 ± 1.6

larynx – bladder

1

0.23

4.3 ± 4.1

pancreas – stomach

23

6.10

3.8 ± 0.8

cervix – stomach

10

2.74

3.7 ± 1.2

esophagus – mouth

4

1.11

3.6 ± 1.9

brain – kidney

19

5.39

3.5 ± 0.8

bladder – testis

18

5.12

3.5 ± 0.9

bladder – prostate

17

5.05

3.4 ± 0.9

bladder – pancreas

11

3.28

3.4 ± 1.1

cervix – lung

20

6.14

3.3 ± 0.8