Table 1 Seven blocks of the significant genes from the rat 1q conservated across rat, mouse and human. The log2-transformed expression of average fold change (average over four tumor samples) for each gene is given in column two with direction up or down indicated by the sign, where genes with average fold change greater than an arbitrary +1.87 and less than -1.87 are highlighted.
Genes | Average Fold changes Log2 | Cytogenetic location (cM) | Descriptions | ||
|---|---|---|---|---|---|
| Â | Â | Rat | Mouse | Human | Â |
Tctex1 | 2.05 | 1q11 | 17 3.1 | Â | t-complex testis expressed 1 |
Slc22a1 | -0.32 | 1q11-q12 | 17 7.34 | 6q26 | solute carrier family 22, member 1 |
Igf2r | 2.53 | 1q11 | 17 7.35 | 6q26 | insulin-like growth factor 2 receptor |
Psmb1 | 1.35 | 1q12 | 17 8.25 | 6q27 | proteasome (prosome, macropain) subunit, beta type 1 |
Calm3 | 3.37 | 1q22 | 7 4.0 | 19q13.2-q13.3 | calmodulin 3 carcinoembryonic antigen-related cell adhesion |
Ceacam1 | -0.40 | 1q21-q22 | 7 5.5 | 19q13.2 | molecule 1 |
Grik5 | 1.92 | 1q21 | 7 6.5 | 19q13.2 | glutamate receptor, ionotropic, kainate 5 |
Zfp36 | 1.04 | 1q21 | 7 10.2 | 19q13.1 | zinc finger protein 36 |
Usf2 | 0.98 | 1q21 | 7 11.0 | 19q13 | transcription factor USF2 |
Sth2 | -1.60 | 1q21.3-q22.1 | 7 A1 | Â | sulfotransferase, hydroxysteroid preferring 2 |
Rps16 | 2.55 | 1q21 | 7 A3 | 19q13.1 | ribosomal protein S16 |
Rps19 | 2.64 | 1q21 | 7 A3 | 19q13.2 | ribosomal protein S19 |
Pafah1b3 | 1.62 | 1q21 | 7 B1 | 19q13.1 | platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit |
Ech1 | 0.92 | 1q21 | 7 B | 19q13.1 | enoyl coenzyme A hydratase 1 |
Atf5 | -0.75 | 1q22 | 7 B3 | 19q13.3 | activating transcription factor 5 |
Myd116 | -0.86 | 1q22 | 7 B3 | Â | myeloid differentiation primary response gene 116 |
Nkg7 | -0.88 | 1q22 | 7 B3 | 19q13.41 | natural killer cell group 7 sequence |
Nucb | 0.96 | 1q22 | 7 B3 | Â | nucleobindin |
Pold1 | 2.06 | 1q22 | 7 23.0 | 19q13.3 | DNA polymerase delta, catalytic subunit |
Emp3 | 0.95 | 1q22 | 7 24.5 | 19q13.3 | epithelial membrane protein 3 |
Tead2 | 2.18 | 1q22 | 7 23.0 | 19q13.3 | TEA domain family member 2 |
Bax | 1.65 | 1q31.2 | 7 23.0 | 19q13.3-q13.4 | Bcl2-associated X protein |
Fzd4 | 0.55 | 1q32 | 7 44.5 | 11q14.2 | frizzled homolog 4 (Drosophila) |
Nox4 | 0.85 | 1q32 | 7 D3 | 11q14.2-q21 | NADPH oxidase 4 |
Rps3 | -2.43 | 1q32 | 7 E1 | 11q13.3-q13.5 | ribosomal protein S3 |
Skd3 | 1.28 | 1q32 | 7 E1 | 11q13.3 | suppressor of K+ transport defect 3 |
Thrsp | 0.23 | 1q32 | 7 E1 | 11q13.5 | thyroid hormone responsive protein |
Ccnd1 | -0.43 | 1q42 | 7 72.3 | 11q13 | cyclin D1 |
Ppp1ca | 1.92 | 1q43 | 7 E3-F2 | 11q13 | protein phosphatase 1, catalytic subunit, alpha isoform |
Cfl1 | 2.83 | 1q43 | 19 A | 11q13 | cofilin 1 |
Fen1 | 4.79 | 1q43 | 19 A | 11q12 | Flap structure-specific endonuclease 1 |
Gstp2 | 1.43 | 1q42 | 19 0.0 | Â | glutathione S-transferase, pi 2 |
Cpt1a | -0.42 | 1q43 | 19 2.0 | 11q13.1-q13.2 | carnitine palmitoyltransferase 1, liver |
Plcb3 | 1.39 | 1q43 | 19 2.5 | 11q13 | phospholipase C, beta 3 |
Chk | 1.06 | 1q42 | 19 3.0 | 11q13.1 | choline kinase |
Emk(Mark2) | 1.63 | 1q43 | 19 3.0 | 11q12-q13 | MAP/microtubule affinity-regulating kinase 2 membrane-spanning 4-domains, subfamily A, member |
Ms4a2 | -0.83 | 1q43 | 19 8.0 | 11q13 | 2 |
Ilk | 1.47 | 1q33 | 7 E1 | 11p15.5-p15.4 | integrin-linked kinase |
Arhg | 1.66 | 1 | 7 E2 | 11p15.5-p15.4 | Ras homolog gene family, member G |
Mrpl17 | 0.94 | 1q33 | 7 E3 | 11p15.5-p15.4 | mitochondrial ribosomal protein L17 |
Arntl | 3.58 | 1q34 | 7 52.0 | 11p15 | aryl hydrocarbon receptor nuclear translocator-like |
Cd81 | -0.60 | 1q41 | 7 69.3 | 11p15.5 | CD 81 antigen |
Tssc3 | 2.00 | 1q41 | 7 69.5 | 11p15.5 | pleckstrin homology-like domain, family A, member 2 |
Tnni2 | 0.97 | 1q41 | 7 70.0 | 11p15.5 | troponin 1, type 2 |
Cdkn1c(p57) | 4.28 | 1q42 | 7 69.49 | 11p15.5 | cyclin-dependent kinase inhibitor 1C, p57 |
Coro1a | 1.10 | 1q36 | 7 62.5 | 16p12.1 | coronin, actin binding protein 1A |
Mapk3 | 1.80 | 1q36 | 7 61.0 | 16p12-p11.2 | protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1) |
Maz | 1.97 | Â | 7 F3 | 16p11.2 | MYC-associated zinc finger protein (purine-binding transcription factor) |
Ppp4c | 1.23 | 1q36 | 7 F3 | 16p12-16p11 | protein phosphatase 4 (formerly X), catalytic subunit |
Umod | -0.88 | 1q36-q37 | 7 55.0 | 16p13.11 | uromodulin |
Fgfr2 | -0.68 | 1q37 | 7 63.0 | 10q26 | fibroblast growth factor receptor 2 |
Cyp2e1 | -0.08 | 1q41-42 | 7 68 | 10q24.3 | cytochrome P450, family 2, subfamily e, polypeptide 1 |
Echs1 | -0.38 | 1q41 | 7 F4 | 10q26.2-q26.3 | enoyl Coenzyme A hydratase, short chain 1 |
Oat | -0.12 | 1q41 | 7 63.0 | 10q26 | ornithine aminotransferase |
Scd1 | 0.40 | 1q54 | 19 43.0 | Â | stearoyl-Coenzyme A desaturase 1 |
Pitx3 | 0.95 | 1q54 | 19 46.5 | 10q25 | paired-like homeodomain transcription factor 3 |
Add3 | 1.81 | 1q55 | 19 47.0 | 10q24.2-q24.3 | adducin 3, gamma |
Cspg6 | 2.73 | 1q55 | 19 D2 | 10q25 | chondroitin sulfate proteoglycan 6 |
Cyp17 | -0.64 | 1q55 | 19 46.0 | 10q24.3 | cytochrome P450, subfamily 17 |
Pnliprp1 | -0.87 | 1q55 | 19 29.0 | 10q26.12 | pancreatic lipase related protein 1 |
Pdcd4 | 1.01 | 1q55 | 19 20.0 | 10q24 | programmed cell death 4 |