Table 2 Conditional probabilities that two core promoter elements are spaced in a synergistically-favorable manner, given that both elements are present
From: Genome-wide analysis of core promoter elements from conserved human and mouse orthologous pairs
Core promoter element pairs | p(synergy | both elements present) | One-tailed significance of synergy | p(synergy | both elements present and conserved in mouse counterparts) | One-tailed significance of synergy | ||
|---|---|---|---|---|---|---|
Real sequences | Randomized sequences | Real sequences | Randomized sequences | |||
TATA-MTE | 0.75 | 0.57 | 2.3 × 10-17 | 0.72 | 0.45 | 2.3 × 10-17 |
BRE-Inr | 0.54 | 0.46 | 4.0 × 10-5 | 0.45 | 0.31 | 7.2 × 10-8 |
TATA-Inr | 0.68 | 0.69 | 0.67 | 0.67 | 0.60 | 0.01 |
BRE-DPE | 0.43 | 0.42 | 0.46 | 0.32 | 0.24 | 0.10 |
Inr-DPE | 0.48 | 0.47 | 0.20 | 0.42 | 0.33 | 0.00 |
MTE-DPE | 0.45 | 0.49 | 0.98 | 0.33 | 0.24 | 0.00 |
Inr-MTE | 0.53 | 0.46 | 1.9 × 10-8 | 0.44 | 0.34 | 3.9 × 10-17 |
BRE-TATA | 0.45 | 0.38 | 0.08 | 0.46 | 0.08 | 0.00 |
BRE-MTE | 0.31 | 0.27 | 0.00 | 0.2 | 0.12 | 5.4 × 10-7 |
TATA-DPE | 0.5 | 0.45 | 0.11 | 0.45 | 0.22 | 0.00 |