Figure 3

First extracted sub-graph. Green boxes indicate significant up-regulation (p-value ≤ 0.05) under anaerobic conditions. Red boxes indicate significant down-regulation and grey boxes non-significant differential regulation. Red/green frames of grey boxes indicate a non-significant tendency. Glucose is catabolised into pyruvate. Under anaerobic conditions, pyruvate is degraded to formic acid (formate), which is either expelled (via transporters), or further degraded into H₂ and CO₂. The reactions for these processes were up-regulated whereas the biosynthesis and degradation of costly compounds were down-regulated (folate and 10-formyl-THF, respectively).