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Table 2 Uniquely over-represented functional categories for DEGs obtained from each probe set algorithm from the experimental diabetes dataset.

From: Utilization of two sample t-test statistics from redundant probe sets to evaluate different probe set algorithms in GeneChip studies

Functional categories a

p-value

Functional categories

p-value

MAS5.0:

 

dChip-PM/MM:

 

Proteolysis and peptidolysis

0.008

Negative regulation of transcription*

0.024

Ubiquitin-dependent protein catabolism

0.013

Response to stress*

0.024

Modification-dependent protein catabolism

0.015

Phosphagen biosynthesis*b

0.043

Intracellular protein transport

0.018

Muscle development

0.033

Intracellular signaling cascade*

0.025

Striated muscle contraction

0.043

Lipoprotein biosynthesis*

0.038

dChip-PM:

 

Protein lipidation

0.039

Fatty acid metabolism*

0.001

Steroid metabolism*

0.047

Organic acid metabolism

0.001

  

Perception of smell

0.037

RMA:

 

Sensory perception of chemical stimulus

0.049

Innate immune response

0.016

  

Acetyl-COA metabolism

0.018

  

Gutamate signaling pathway

0.034

  

Inflammatory response

0.040

  
  1. * Categories known to be directly related to diabetes.
  2. a. Biological process generated by DAVID 2.0 [21] as of Oct. 6, 2005.
  3. b. Genes in the function category are involved in energy metabolism.
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BMC Bioinformatics

ISSN: 1471-2105

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