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Figure 3 | BMC Bioinformatics

Figure 3

From: Application of a sensitive collection heuristic for very large protein families: Evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases

Figure 3

The conserved ancestral core module: The phylogenetic tree. The tree depicts the evolutionary relationship between the sequence segments that are included in the multiple alignment (Figure 2). The upper part of the tree contains the protein segments that were found with pancreatic lipase as seed for the FAMILYSEARCHER procedure, while the lower part contains the results of the patatin family-search. The starting sequences for the iterative procedures each have an asterix between parentheses (*) after the accession number. Important spots of the tree are marked by a bracket that is followed by a short description. Here, the classic lipases in the alignment are hepatic lipase (AAA59221), lipoprotein lipase (AAP35372), endothelial lipase (NP_006024) and pancreatic lipase (P16233). The bottom of the tree also contains three type A2 cytosolic phospholipases. Besides patatin (1OXW, [13]), this is the second type of protein from the pooled results that has been shown to function via a catalytic dyad (1CJY, [14]).

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BMC Bioinformatics

ISSN: 1471-2105

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