Figure 1
![Figure 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1471-2105-7-167/MediaObjects/12859_2005_Article_906_Fig1_HTML.jpg)
Increase in affinity of α-MSH predicted from the binary proteochemometric model. Shown is the increase in affinity SU (log(M)) for α-MSH afforded by swapping each of segments S1 – S5 in the MC4 receptor with the corresponding segment in the MC1 receptor as predicted from the binary proteochemometrics model.