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Table 2 PC7 High Extreme Genes. Detailed info for (n = 88) extreme genes in PC7 set H 7 , ordered most extreme first, including common name, description, and associated Gene Ontology terms (provided with the GNF dataset). These extreme genes are shown as red points in Figure 1.

From: Mining gene expression data by interpreting principal components

PC-7 Value Name Description Function
18.63 COL1A2 collagen, type I, alpha 2 (GO:0006817) phosphate transport; (GO:0001501) skeletal development; (GO:0008147) structural constituent of bone;
17.89 LUM lumican (GO:0005518) collagen binding; (GO:0030199) collagen fibril organization; (GO:0005207) extracellular matrix glycoprotein; (GO:0005201) extracellular matrix structural constituent; (GO:0005203) proteoglycan; (GO:0007601) visual perception;
15.48 TPM2 tropomyosin 2 (beta) (GO:0003779) actin binding; (GO:0007517) muscle development; (GO:0008307) structural constituent of muscle;
15.30 IGFBP7 insulin-like growth factor binding protein 7 (GO:0005520) insulin-like growth factor binding; (GO:0008285) negative regulation of cell proliferation; (GO:0001558) regulation of cell growth;
14.54 CAV1 caveolin 1, caveolae protein, 22 kDa (GO:0005198) structural molecule activity; (GO:0008181) tumor suppressor;
14.08 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) (GO:0008015) circulation; (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0007397) histogenesis and organogenesis; (GO:0009887) organogenesis; (GO:0006817) phosphate transport;
13.84 KCTD12 potassium channel tetramerisation domain containing 12 (GO:0006813) potassium ion transport; (GO:0005515) protein binding; (GO:0005249) voltage-gated potassium channel activity;
13.83 COL1A1 collagen, type I, alpha 1 (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0007605) perception of sound; (GO:0006817) phosphate transport; (GO:0001501) skeletal development; (GO:0008147) structural constituent of bone;
13.71 MGP matrix Gla protein (GO:0005509) calcium ion binding; (GO:0005201) extracellular matrix structural constituent; (GO:0007048) oncogenesis; (GO:0007605) perception of sound; (GO:0008147) structural constituent of bone;
13.57 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) (GO:0008015) circulation; (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0007397) histogenesis and organogenesis; (GO:0009887) organogenesis; (GO:0006817) phosphate transport;
13.25 CALD1 caldesmon 1 (GO:0003779) actin binding; (GO:0005516) calmodulin binding; (GO:0006936) muscle contraction; (GO:0007517) muscle development; (GO:0017022) myosin binding; (GO:0005523) tropomyosin binding
13.19 MYL9 myosin, light polypeptide 9, regulatory (GO:0005509) calcium ion binding; (GO:0008307) structural constituent of muscle
13.12 FN1 fibronectin 1 (GO:0006953) acute-phase response; (GO:0007155) cell adhesion; (GO:0016477) cell migration; (GO:0005518) collagen binding; (GO:0005201) extracellular matrix structural constituent; (GO:0008201) heparin binding; (GO:0009611) response to wounding
12.71 PLK2 polo-like kinase 2 (Drosophila) (GO:0005524) ATP binding; (GO:0043123) positive regulation of I-kappaB kinase/NF-kappaB cascade; (GO:0006468) protein amino acid phosphorylation; (GO:0004674) protein serine/threonine kinase activity; (GO:0004871) signal transducer activity; (GO:0016740) transferase activity
12.59 CALD1 caldesmon 1 (GO:0003779) actin binding; (GO:0005516) calmodulin binding; (GO:0006936) muscle contraction; (GO:0007517) muscle development; (GO:0017022) myosin binding; (GO:0005523) tropomyosin binding
12.54 CTGF connective tissue growth factor (GO:0006259) DNA metabolism; (GO:0007155) cell adhesion; (GO:0005194) cell adhesion molecule activity; (GO:0008151) cell growth and/or maintenance; (GO:0006928) cell motility; (GO:0008201) heparin binding; (GO:0005520) insulin-like growth factor binding; (GO:0005515) protein binding; (GO:0001558) regulation of cell growth; (GO:0009611) response to wounding
12.39 D2S448 Melanoma associated gene (GO:0006955) immune response; (GO:0005152) interleukin-1 receptor antagonist activity; (GO:0004601) peroxidase activity
12.28 MFAP5 microfibrillar associated protein 5 (GO:0005201) extracellular matrix structural constituent
12.24 SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C (GO:0008151) cell growth and/or maintenance; (GO:0007275) development; (GO:0009315) drug resistance; (GO:0006955) immune response; (GO:0042493) response to drug
12.20 ADAMTS1 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1 (GO:0008201) heparin binding; (GO:0016787) hydrolase activity; (GO:0005178) integrin binding; (GO:0007229) integrin-mediated signaling pathway; (GO:0004222) metalloendopeptidase activity; (GO:0008237) metallopeptidase activity; (GO:0008285) negative regulation of cell proliferation; (GO:0006508) proteolysis and peptidolysis; (GO:0008270) zinc ion binding
11.99 SPARC secreted protein, acidic, cysteine-rich (osteonectin) (GO:0005509) calcium ion binding; (GO:0005518) collagen binding
11.76 F3 coagulation factor III (thromboplastin, tissue factor) (GO:0007596) blood coagulation; (GO:0003801) blood coagulation factor activity; (GO:0004896) hematopoietin/interferon-class (D200-domain) cytokine receptor activity; (GO:0006955) immune response; (GO:0004872) receptor activity; (GO:0004888) transmembrane receptor activity
11.71 PLS3 plastin 3 (T isoform) (GO:0003779) actin binding; (GO:0005509) calcium ion binding
11.70 THBS1 thrombospondin 1 (GO:0007596) blood coagulation; (GO:0005509) calcium ion binding; (GO:0007155) cell adhesion; (GO:0005194) cell adhesion molecule activity; (GO:0006928) cell motility; (GO:0007275) development; (GO:0004866) endopeptidase inhibitor activity; (GO:0008201) heparin binding; (GO:0007399) neurogenesis; (GO:0005515) protein binding; (GO:0004871) signal transducer activity; (GO:0005198) structural molecule activity
11.69 PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 (GO:0016491) oxidoreductase activity; (GO:0016702) oxidoreductase activity\, acting on single donors with incorporation of molecular oxygen\, incorporation of two atoms of oxygen; (GO:0008475) procollagen-lysine 5-dioxygenase activity; (GO:0019538) protein metabolism; (GO:0006464) protein modification
11.37 CAV1 caveolin 1, caveolae protein, 22 kDa (GO:0005198) structural molecule activity; (GO:0008181) tumor suppressor
11.36 gnf1h04130_x_at None None
11.28 FN1 fibronectin 1 (GO:0006953) acute-phase response; (GO:0007155) cell adhesion; (GO:0016477) cell migration; (GO:0005518) collagen binding; (GO:0005201) extracellular matrix structural constituent; (GO:0008201) heparin binding; (GO:0009611) response to wounding
11.18 SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (GO:0005524) ATP binding; (GO:0008026) ATP-dependent helicase activity; (GO:0003677) DNA binding; (GO:0004002) adenosinetriphosphatase; (GO:0006338) chromatin remodeling; (GO:0004386) helicase activity; (GO:0045182) translation regulator activity
11.08 TAGLN transgelin (GO:0007517) Muscle development
10.95 COL4A1 collagen, type IV, alpha 1 (GO:0003677) DNA binding; (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0006817) phosphate transport
10.90 CAV2 caveolin 2 (GO:0008181) tumor suppressor
10.90 TPM1 tropomyosin 1 (alpha) (GO:0003779) actin binding; (GO:0007517) muscle development; (GO:0008016) regulation of heart rate; (GO:0005200) structural constituent of cytoskeleton; (GO:0008307) structural constituent of muscle
10.85 GJA1 gap junction protein, alpha 1, 43 kDa (connexin 43) (GO:0007267) cell-cell signaling; (GO:0015285) connexon channel activity; (GO:0007507) heart development; (GO:0015075) ion transporter activity; (GO:0006936) muscle contraction; (GO:0007605) perception of sound; (GO:0043123) positive regulation of I-kappaB kinase/NF-kappaB cascade; (GO:0004871) signal transducer activity; (GO:0006832) small molecule transport; (GO:0006810) transport
10.82 COL1A2 collagen, type I, alpha 2 (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0006817) phosphate transport; (GO:0001501) skeletal development; (GO:0008147) structural constituent of bone
10.61 FXR1 fragile X mental retardation, autosomal homolog 1 (GO:0003677) DNA binding; (GO:0003723) RNA binding; (GO:0006915) apoptosis; (GO:0003676) nucleic acid binding; (GO:0006913) nucleocytoplasmic transport
10.60 COL6A3 collagen, type VI, alpha 3 cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);muscle development (GO:0007517);phosphate transport (GO:0006817);protein binding (GO:0005515);serine-type endopeptidase inhibitor activity (GO:0004867)
10.52 CYR61 cysteine-rich, angiogenic inducer, 61 cell adhesion (GO:0007155);cell proliferation (GO:0008283);chemotaxis (GO:0006935);embryogenesis and morphogenesis (GO:0007345);heparin binding (GO:0008201);insulin-like growth factor binding (GO:0005520);morphogenesis (GO:0009653);regulation of cell growth (GO:0001558)
10.50 10-Sep septin 10 GTP binding (GO:0005525)
10.44 IL1R1 interleukin 1 receptor, type I cell surface receptor linked signal transduction (GO:0007166);immune response (GO:0006955);inflammatory response (GO:0006954);interleukin-1 receptor activity (GO:0004908);interleukin-1\, Type I\, activating receptor activity (GO:0004909);signal transducer activity (GO:0004871);transmembrane receptor activity (GO:0004888)
10.37 WBP5 WW domain binding protein 1 DNA binding (GO:0003677)
10.35 LAMB1 laminin, beta 1 cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);protein binding (GO:0005515);structural molecule activity (GO:0005198)
10.33 EMP1 epithelial membrane protein 1 cell death (GO:0008219);cell growth (GO:0016049);cell proliferation (GO:0008283);development (GO:0007275);oncogenesis (GO:0007048)
10.23 NRP1 neuropilin 1 axon guidance (GO:0007411);cell adhesion (GO:0007155);cell-cell signaling (GO:0007267);histogenesis and organogenesis (GO:0007397);neurogenesis (GO:0007399);organogenesis (GO:0009887);positive regulation of cell proliferation (GO:0008284);receptor activity (GO:0004872);signal transduction (GO:0007165);vascular endothelial growth factor receptor activity (GO:0005021)
10.12 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) circulation (GO:0008015);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);histogenesis and organogenesis (GO:0007397);organogenesis (GO:0009887);phosphate transport (GO:0006817)
10.10 CALD1 caldesmon 1 actin binding (GO:0003779);calmodulin binding (GO:0005516);muscle contraction (GO:0006936);muscle development (GO:0007517);myosin binding (GO:0017022);tropomyosin binding (GO:0005523)
10.10 THBS1 thrombospondin 1 blood coagulation (GO:0007596);calcium ion binding (GO:0005509);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);cell motility (GO:0006928);development (GO:0007275);endopeptidase inhibitor activity (GO:0004866);heparin binding (GO:0008201);neurogenesis (GO:0007399);protein binding (GO:0005515);signal transducer activity (GO:0004871);structural molecule activity (GO:0005198)
10.05 FN1 fibronectin 1 acute-phase response (GO:0006953);cell adhesion (GO:0007155);cell migration (GO:0016477);collagen binding (GO:0005518);extracellular matrix structural constituent (GO:0005201);heparin binding (GO:0008201);response to wounding (GO:0009611)
10.03 SPARC secreted protein, acidic, cysteine-rich (osteonectin) calcium ion binding (GO:0005509);collagen binding (GO:0005518)
10.02 IGFBP7 insulin-like growth factor binding protein 7 insulin-like growth factor binding (GO:0005520);negative regulation of cell proliferation (GO:0008285);regulation of cell growth (GO:0001558)
9.99 IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) cell surface receptor linked signal transduction (GO:0007166);gp130 (GO:0004898);immune response (GO:0006955);interleukin-6 receptor activity (GO:0004915);oncostatin-M receptor activity (GO:0004924);receptor activity (GO:0004872);signal transduction (GO:0007165)
9.98 LAMB1 laminin, beta 1 cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);protein binding (GO:0005515);structural molecule activity (GO:0005198)
9.94 TAZ transcriptional co-activator with PDZ-binding motif (TAZ) transcription coactivator activity (GO:0003713)
9.93 DCN decorin chondroitin sulfate/dermatan sulfate proteoglycan (GO:0005205);histogenesis and organogenesis (GO:0007397);organogenesis (GO:0009887)
9.93 ANXA1 annexin A1 calcium ion binding (GO:0005509);calcium-dependent phospholipid binding (GO:0005544);cell motility (GO:0006928);cell surface receptor linked signal transduction (GO:0007166);inflammatory response (GO:0006954);lipid metabolism (GO:0006629);phospholipase A2 inhibitor activity (GO:0019834);phospholipase inhibitor activity (GO:0004859);phospholipid binding (GO:0005543);receptor binding (GO:0005102)
9.89 MYH11 myosin, heavy polypeptide 11, smooth muscle ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);cell growth and/or maintenance (GO:0008151);motor activity (GO:0003774);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941)
9.89 EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 calcium ion binding (GO:0005509);visual perception (GO:0007601)
9.88 SPUVE protease, serine, 23 chymotrypsin activity (GO:0004263);hydrolase activity (GO:0016787);proteolysis and peptidolysis (GO:0006508);trypsin activity (GO:0004295)
9.87 Hs.514018 CDNA: FLJ22209 fis, clone HRC01496 None
9.80 FN1 fibronectin 1 acute-phase response (GO:0006953);cell adhesion (GO:0007155);cell migration (GO:0016477);collagen binding (GO:0005518);extracellular matrix structural constituent (GO:0005201);heparin binding (GO:0008201);response to wounding (GO:0009611)
9.77 COL16A1 collagen, type XVI, alpha 1 cell adhesion (GO:0007155);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);phosphate transport (GO:0006817);pregnancy (GO:0007565)
9.73 SNX7 sorting nexin 7 intracellular protein transport (GO:0006886);intracellular signaling cascade (GO:0007242);protein transporter activity (GO:0008565)
9.69 AHR aryl hydrocarbon receptor DNA binding (GO:0003677);apoptosis (GO:0006915);ligand-dependent nuclear receptor activity (GO:0004879);response to stress (GO:0006950);response to xenobiotic stimulus (GO:0009410);signal transduction (GO:0007165);transcription factor activity (GO:0003700);transcription from Pol II promoter (GO:0006366)
9.57 COL6A1 collagen, type VI, alpha 1 DNA binding (GO:0003677);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);histogenesis and organogenesis (GO:0007397);molecular_function unknown (GO:0005554);phosphate transport (GO:0006817);protein binding (GO:0005515)
9.55 KIAA0992 palladin amino acid metabolism (GO:0006520)
9.54 COL5A2 collagen, type V, alpha 2 cell growth and/or maintenance (GO:0008151);collagen (GO:0005202);extracellular matrix glycoprotein (GO:0005207);extracellular matrix structural constituent (GO:0005201);phosphate transport (GO:0006817)
9.53 FBN1 fibrillin 1 (Marfan syndrome) calcium ion binding (GO:0005509);development (GO:0007275);extracellular matrix structural constituent (GO:0005201);skeletal development (GO:0001501);visual perception (GO:0007601)
9.51 PAM peptidylglycine alpha-amidating monooxygenase electron transporter activity (GO:0005489);monooxygenase activity (GO:0004497);peptide amidation (GO:0001519);peptidylglycine monooxygenase activity (GO:0004504);protein modification (GO:0006464)
9.50 LOC92912 hypothetical protein LOC92912 ligase activity (GO:0016874);ubiquitin conjugating enzyme activity (GO:0004840);ubiquitin cycle (GO:0006512);ubiquitin-protein ligase activity (GO:0004842)
9.47 COL6A2 collagen, type VI, alpha 2 cell-cell adhesion (GO:0016337);collagen (GO:0005202);extracellular matrix organization and biogenesis (GO:0030198);extracellular matrix structural constituent (GO:0005201);muscle development (GO:0007517);phosphate transport (GO:0006817);protein binding, bridging (GO:0030674)
9.45 PTX1 PTX1 protein None
9.41 KIAA0992 palladin amino acid metabolism (GO:0006520)
9.33 CSPG2 chondroitin sulfate proteoglycan 2 (versican) calcium ion binding (GO:0005509);cell adhesion (GO:0007155);chondroitin sulfate proteoglycan (GO:0005204);development (GO:0007275);glycosaminoglycan binding (GO:0005539);heterophilic cell adhesion (GO:0007157);hyaluronic acid binding (GO:0005540);lectin (GO:0005530);proteoglycan (GO:0005203);sugar binding (GO:0005529)
9.32 CSPG2 chondroitin sulfate proteoglycan 2 (versican) calcium ion binding (GO:0005509);cell adhesion (GO:0007155);chondroitin sulfate proteoglycan (GO:0005204);development (GO:0007275);glycosaminoglycan binding (GO:0005539);heterophilic cell adhesion (GO:0007157);hyaluronic acid binding (GO:0005540);lectin (GO:0005530);proteoglycan (GO:0005203);sugar binding (GO:0005529)
9.30 SERPINH1 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) collagen binding (GO:0005518);heat shock protein activity (GO:0003773);response to stress (GO:0006950);serine-type endopeptidase inhibitor activity (GO:0004867);serpin (GO:0004868)
9.23 TM4SF6 transmembrane 4 superfamily member 6 cell adhesion molecule activity (GO:0005194);cell motility (GO:0006928);positive regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043123);signal transducer activity (GO:0004871)
9.20 PTRF polymerase I and transcript release factor None
9.19 LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) ATP binding (GO:0005524);protein amino acid phosphorylation (GO:0006468);protein serine/threonine kinase activity (GO:0004674);transferase activity (GO:0016740);tumor suppressor (GO:0008181)
9.12 CTBP2 C-terminal binding protein 2 L-serine biosynthesis (GO:0006564);negative regulation of cell proliferation (GO:0008285);oxidoreductase activity (GO:0016491);oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616);tumor suppressor (GO:0008181);viral replication (GO:0008166)
9.06 ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) cell adhesion (GO:0007155);cell adhesion receptor activity (GO:0004895);cell-matrix adhesion (GO:0007160);integrin-mediated signaling pathway (GO:0007229);protein binding (GO:0005515)
9.05 RCN2 reticulocalbin 2, EF-hand calcium binding domain calcium ion binding (GO:0005509);protein binding (GO:0005515);tumor suppressor (GO:0008181)
8.98 CPD carboxypeptidase D carboxypeptidase A activity (GO:0004182);carboxypeptidase D activity (GO:0004187);carboxypeptidase activity (GO:0004180);hydrolase activity (GO:0016787);proteolysis and peptidolysis (GO:0006508);zinc ion binding (GO:0008270)
8.98 FLJ21174 hypothetical protein FLJ21174 None
8.96 MGC5395 hypothetical protein MGC5395 intracellular signaling cascade (GO:0007242);neurogenesis (GO:0007399);protein binding (GO:0005515)
8.96 MFAP2 microfibrillar-associated protein 2 extracellular matrix glycoprotein (GO:0005207);extracellular matrix structural constituent (GO:0005201)
8.94 CRIM1 cysteine-rich motor neuron 1 cysteine-type endopeptidase activity (GO:0004197);insulin-like growth factor binding (GO:0005520);insulin-like growth factor receptor activity (GO:0005010);neurogenesis (GO:0007399);proteolysis and peptidolysis (GO:0006508);regulation of cell growth (GO:0001558);serine-type endopeptidase inhibitor activity (GO:0004867)
8.92 ALDH1A3 aldehyde dehydrogenase 1 family, member A3 alcohol metabolism (GO:0006066);aldehyde dehydrogenase [NAD(P)+] activity (GO:0004030);aldehyde dehydrogenase activity (GO:0004028);lipid metabolism (GO:0006629);metabolism (GO:0008152);oxidoreductase activity (GO:0016491)
8.92 MGC34132 hypothetical protein MGC34132 None