Table 2 PC7 High Extreme Genes. Detailed info for (n = 88) extreme genes in PC7 set H 7 , ordered most extreme first, including common name, description, and associated Gene Ontology terms (provided with the GNF dataset). These extreme genes are shown as red points in Figure 1.
From: Mining gene expression data by interpreting principal components
PC-7 Value | Name | Description | Function |
|---|---|---|---|
18.63 | COL1A2 | collagen, type I, alpha 2 | (GO:0006817) phosphate transport; (GO:0001501) skeletal development; (GO:0008147) structural constituent of bone; |
17.89 | LUM | lumican | (GO:0005518) collagen binding; (GO:0030199) collagen fibril organization; (GO:0005207) extracellular matrix glycoprotein; (GO:0005201) extracellular matrix structural constituent; (GO:0005203) proteoglycan; (GO:0007601) visual perception; |
15.48 | TPM2 | tropomyosin 2 (beta) | (GO:0003779) actin binding; (GO:0007517) muscle development; (GO:0008307) structural constituent of muscle; |
15.30 | IGFBP7 | insulin-like growth factor binding protein 7 | (GO:0005520) insulin-like growth factor binding; (GO:0008285) negative regulation of cell proliferation; (GO:0001558) regulation of cell growth; |
14.54 | CAV1 | caveolin 1, caveolae protein, 22 kDa | (GO:0005198) structural molecule activity; (GO:0008181) tumor suppressor; |
14.08 | COL3A1 | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | (GO:0008015) circulation; (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0007397) histogenesis and organogenesis; (GO:0009887) organogenesis; (GO:0006817) phosphate transport; |
13.84 | KCTD12 | potassium channel tetramerisation domain containing 12 | (GO:0006813) potassium ion transport; (GO:0005515) protein binding; (GO:0005249) voltage-gated potassium channel activity; |
13.83 | COL1A1 | collagen, type I, alpha 1 | (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0007605) perception of sound; (GO:0006817) phosphate transport; (GO:0001501) skeletal development; (GO:0008147) structural constituent of bone; |
13.71 | MGP | matrix Gla protein | (GO:0005509) calcium ion binding; (GO:0005201) extracellular matrix structural constituent; (GO:0007048) oncogenesis; (GO:0007605) perception of sound; (GO:0008147) structural constituent of bone; |
13.57 | COL3A1 | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | (GO:0008015) circulation; (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0007397) histogenesis and organogenesis; (GO:0009887) organogenesis; (GO:0006817) phosphate transport; |
13.25 | CALD1 | caldesmon 1 | (GO:0003779) actin binding; (GO:0005516) calmodulin binding; (GO:0006936) muscle contraction; (GO:0007517) muscle development; (GO:0017022) myosin binding; (GO:0005523) tropomyosin binding |
13.19 | MYL9 | myosin, light polypeptide 9, regulatory | (GO:0005509) calcium ion binding; (GO:0008307) structural constituent of muscle |
13.12 | FN1 | fibronectin 1 | (GO:0006953) acute-phase response; (GO:0007155) cell adhesion; (GO:0016477) cell migration; (GO:0005518) collagen binding; (GO:0005201) extracellular matrix structural constituent; (GO:0008201) heparin binding; (GO:0009611) response to wounding |
12.71 | PLK2 | polo-like kinase 2 (Drosophila) | (GO:0005524) ATP binding; (GO:0043123) positive regulation of I-kappaB kinase/NF-kappaB cascade; (GO:0006468) protein amino acid phosphorylation; (GO:0004674) protein serine/threonine kinase activity; (GO:0004871) signal transducer activity; (GO:0016740) transferase activity |
12.59 | CALD1 | caldesmon 1 | (GO:0003779) actin binding; (GO:0005516) calmodulin binding; (GO:0006936) muscle contraction; (GO:0007517) muscle development; (GO:0017022) myosin binding; (GO:0005523) tropomyosin binding |
12.54 | CTGF | connective tissue growth factor | (GO:0006259) DNA metabolism; (GO:0007155) cell adhesion; (GO:0005194) cell adhesion molecule activity; (GO:0008151) cell growth and/or maintenance; (GO:0006928) cell motility; (GO:0008201) heparin binding; (GO:0005520) insulin-like growth factor binding; (GO:0005515) protein binding; (GO:0001558) regulation of cell growth; (GO:0009611) response to wounding |
12.39 | D2S448 | Melanoma associated gene | (GO:0006955) immune response; (GO:0005152) interleukin-1 receptor antagonist activity; (GO:0004601) peroxidase activity |
12.28 | MFAP5 | microfibrillar associated protein 5 | (GO:0005201) extracellular matrix structural constituent |
12.24 | SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | (GO:0008151) cell growth and/or maintenance; (GO:0007275) development; (GO:0009315) drug resistance; (GO:0006955) immune response; (GO:0042493) response to drug |
12.20 | ADAMTS1 | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1 | (GO:0008201) heparin binding; (GO:0016787) hydrolase activity; (GO:0005178) integrin binding; (GO:0007229) integrin-mediated signaling pathway; (GO:0004222) metalloendopeptidase activity; (GO:0008237) metallopeptidase activity; (GO:0008285) negative regulation of cell proliferation; (GO:0006508) proteolysis and peptidolysis; (GO:0008270) zinc ion binding |
11.99 | SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | (GO:0005509) calcium ion binding; (GO:0005518) collagen binding |
11.76 | F3 | coagulation factor III (thromboplastin, tissue factor) | (GO:0007596) blood coagulation; (GO:0003801) blood coagulation factor activity; (GO:0004896) hematopoietin/interferon-class (D200-domain) cytokine receptor activity; (GO:0006955) immune response; (GO:0004872) receptor activity; (GO:0004888) transmembrane receptor activity |
11.71 | PLS3 | plastin 3 (T isoform) | (GO:0003779) actin binding; (GO:0005509) calcium ion binding |
11.70 | THBS1 | thrombospondin 1 | (GO:0007596) blood coagulation; (GO:0005509) calcium ion binding; (GO:0007155) cell adhesion; (GO:0005194) cell adhesion molecule activity; (GO:0006928) cell motility; (GO:0007275) development; (GO:0004866) endopeptidase inhibitor activity; (GO:0008201) heparin binding; (GO:0007399) neurogenesis; (GO:0005515) protein binding; (GO:0004871) signal transducer activity; (GO:0005198) structural molecule activity |
11.69 | PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 | (GO:0016491) oxidoreductase activity; (GO:0016702) oxidoreductase activity\, acting on single donors with incorporation of molecular oxygen\, incorporation of two atoms of oxygen; (GO:0008475) procollagen-lysine 5-dioxygenase activity; (GO:0019538) protein metabolism; (GO:0006464) protein modification |
11.37 | CAV1 | caveolin 1, caveolae protein, 22 kDa | (GO:0005198) structural molecule activity; (GO:0008181) tumor suppressor |
11.36 | gnf1h04130_x_at | None | None |
11.28 | FN1 | fibronectin 1 | (GO:0006953) acute-phase response; (GO:0007155) cell adhesion; (GO:0016477) cell migration; (GO:0005518) collagen binding; (GO:0005201) extracellular matrix structural constituent; (GO:0008201) heparin binding; (GO:0009611) response to wounding |
11.18 | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | (GO:0005524) ATP binding; (GO:0008026) ATP-dependent helicase activity; (GO:0003677) DNA binding; (GO:0004002) adenosinetriphosphatase; (GO:0006338) chromatin remodeling; (GO:0004386) helicase activity; (GO:0045182) translation regulator activity |
11.08 | TAGLN | transgelin | (GO:0007517) Muscle development |
10.95 | COL4A1 | collagen, type IV, alpha 1 | (GO:0003677) DNA binding; (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0006817) phosphate transport |
10.90 | CAV2 | caveolin 2 | (GO:0008181) tumor suppressor |
10.90 | TPM1 | tropomyosin 1 (alpha) | (GO:0003779) actin binding; (GO:0007517) muscle development; (GO:0008016) regulation of heart rate; (GO:0005200) structural constituent of cytoskeleton; (GO:0008307) structural constituent of muscle |
10.85 | GJA1 | gap junction protein, alpha 1, 43 kDa (connexin 43) | (GO:0007267) cell-cell signaling; (GO:0015285) connexon channel activity; (GO:0007507) heart development; (GO:0015075) ion transporter activity; (GO:0006936) muscle contraction; (GO:0007605) perception of sound; (GO:0043123) positive regulation of I-kappaB kinase/NF-kappaB cascade; (GO:0004871) signal transducer activity; (GO:0006832) small molecule transport; (GO:0006810) transport |
10.82 | COL1A2 | collagen, type I, alpha 2 | (GO:0005202) collagen; (GO:0005201) extracellular matrix structural constituent; (GO:0006817) phosphate transport; (GO:0001501) skeletal development; (GO:0008147) structural constituent of bone |
10.61 | FXR1 | fragile X mental retardation, autosomal homolog 1 | (GO:0003677) DNA binding; (GO:0003723) RNA binding; (GO:0006915) apoptosis; (GO:0003676) nucleic acid binding; (GO:0006913) nucleocytoplasmic transport |
10.60 | COL6A3 | collagen, type VI, alpha 3 | cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);muscle development (GO:0007517);phosphate transport (GO:0006817);protein binding (GO:0005515);serine-type endopeptidase inhibitor activity (GO:0004867) |
10.52 | CYR61 | cysteine-rich, angiogenic inducer, 61 | cell adhesion (GO:0007155);cell proliferation (GO:0008283);chemotaxis (GO:0006935);embryogenesis and morphogenesis (GO:0007345);heparin binding (GO:0008201);insulin-like growth factor binding (GO:0005520);morphogenesis (GO:0009653);regulation of cell growth (GO:0001558) |
10.50 | 10-Sep | septin 10 | GTP binding (GO:0005525) |
10.44 | IL1R1 | interleukin 1 receptor, type I | cell surface receptor linked signal transduction (GO:0007166);immune response (GO:0006955);inflammatory response (GO:0006954);interleukin-1 receptor activity (GO:0004908);interleukin-1\, Type I\, activating receptor activity (GO:0004909);signal transducer activity (GO:0004871);transmembrane receptor activity (GO:0004888) |
10.37 | WBP5 | WW domain binding protein 1 | DNA binding (GO:0003677) |
10.35 | LAMB1 | laminin, beta 1 | cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);protein binding (GO:0005515);structural molecule activity (GO:0005198) |
10.33 | EMP1 | epithelial membrane protein 1 | cell death (GO:0008219);cell growth (GO:0016049);cell proliferation (GO:0008283);development (GO:0007275);oncogenesis (GO:0007048) |
10.23 | NRP1 | neuropilin 1 | axon guidance (GO:0007411);cell adhesion (GO:0007155);cell-cell signaling (GO:0007267);histogenesis and organogenesis (GO:0007397);neurogenesis (GO:0007399);organogenesis (GO:0009887);positive regulation of cell proliferation (GO:0008284);receptor activity (GO:0004872);signal transduction (GO:0007165);vascular endothelial growth factor receptor activity (GO:0005021) |
10.12 | COL3A1 | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | circulation (GO:0008015);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);histogenesis and organogenesis (GO:0007397);organogenesis (GO:0009887);phosphate transport (GO:0006817) |
10.10 | CALD1 | caldesmon 1 | actin binding (GO:0003779);calmodulin binding (GO:0005516);muscle contraction (GO:0006936);muscle development (GO:0007517);myosin binding (GO:0017022);tropomyosin binding (GO:0005523) |
10.10 | THBS1 | thrombospondin 1 | blood coagulation (GO:0007596);calcium ion binding (GO:0005509);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);cell motility (GO:0006928);development (GO:0007275);endopeptidase inhibitor activity (GO:0004866);heparin binding (GO:0008201);neurogenesis (GO:0007399);protein binding (GO:0005515);signal transducer activity (GO:0004871);structural molecule activity (GO:0005198) |
10.05 | FN1 | fibronectin 1 | acute-phase response (GO:0006953);cell adhesion (GO:0007155);cell migration (GO:0016477);collagen binding (GO:0005518);extracellular matrix structural constituent (GO:0005201);heparin binding (GO:0008201);response to wounding (GO:0009611) |
10.03 | SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | calcium ion binding (GO:0005509);collagen binding (GO:0005518) |
10.02 | IGFBP7 | insulin-like growth factor binding protein 7 | insulin-like growth factor binding (GO:0005520);negative regulation of cell proliferation (GO:0008285);regulation of cell growth (GO:0001558) |
9.99 | IL6ST | interleukin 6 signal transducer (gp130, oncostatin M receptor) | cell surface receptor linked signal transduction (GO:0007166);gp130 (GO:0004898);immune response (GO:0006955);interleukin-6 receptor activity (GO:0004915);oncostatin-M receptor activity (GO:0004924);receptor activity (GO:0004872);signal transduction (GO:0007165) |
9.98 | LAMB1 | laminin, beta 1 | cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);protein binding (GO:0005515);structural molecule activity (GO:0005198) |
9.94 | TAZ | transcriptional co-activator with PDZ-binding motif (TAZ) | transcription coactivator activity (GO:0003713) |
9.93 | DCN | decorin | chondroitin sulfate/dermatan sulfate proteoglycan (GO:0005205);histogenesis and organogenesis (GO:0007397);organogenesis (GO:0009887) |
9.93 | ANXA1 | annexin A1 | calcium ion binding (GO:0005509);calcium-dependent phospholipid binding (GO:0005544);cell motility (GO:0006928);cell surface receptor linked signal transduction (GO:0007166);inflammatory response (GO:0006954);lipid metabolism (GO:0006629);phospholipase A2 inhibitor activity (GO:0019834);phospholipase inhibitor activity (GO:0004859);phospholipid binding (GO:0005543);receptor binding (GO:0005102) |
9.89 | MYH11 | myosin, heavy polypeptide 11, smooth muscle | ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);cell growth and/or maintenance (GO:0008151);motor activity (GO:0003774);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941) |
9.89 | EFEMP1 | EGF-containing fibulin-like extracellular matrix protein 1 | calcium ion binding (GO:0005509);visual perception (GO:0007601) |
9.88 | SPUVE | protease, serine, 23 | chymotrypsin activity (GO:0004263);hydrolase activity (GO:0016787);proteolysis and peptidolysis (GO:0006508);trypsin activity (GO:0004295) |
9.87 | Hs.514018 | CDNA: FLJ22209 fis, clone HRC01496 | None |
9.80 | FN1 | fibronectin 1 | acute-phase response (GO:0006953);cell adhesion (GO:0007155);cell migration (GO:0016477);collagen binding (GO:0005518);extracellular matrix structural constituent (GO:0005201);heparin binding (GO:0008201);response to wounding (GO:0009611) |
9.77 | COL16A1 | collagen, type XVI, alpha 1 | cell adhesion (GO:0007155);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);phosphate transport (GO:0006817);pregnancy (GO:0007565) |
9.73 | SNX7 | sorting nexin 7 | intracellular protein transport (GO:0006886);intracellular signaling cascade (GO:0007242);protein transporter activity (GO:0008565) |
9.69 | AHR | aryl hydrocarbon receptor | DNA binding (GO:0003677);apoptosis (GO:0006915);ligand-dependent nuclear receptor activity (GO:0004879);response to stress (GO:0006950);response to xenobiotic stimulus (GO:0009410);signal transduction (GO:0007165);transcription factor activity (GO:0003700);transcription from Pol II promoter (GO:0006366) |
9.57 | COL6A1 | collagen, type VI, alpha 1 | DNA binding (GO:0003677);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);collagen (GO:0005202);extracellular matrix structural constituent (GO:0005201);histogenesis and organogenesis (GO:0007397);molecular_function unknown (GO:0005554);phosphate transport (GO:0006817);protein binding (GO:0005515) |
9.55 | KIAA0992 | palladin | amino acid metabolism (GO:0006520) |
9.54 | COL5A2 | collagen, type V, alpha 2 | cell growth and/or maintenance (GO:0008151);collagen (GO:0005202);extracellular matrix glycoprotein (GO:0005207);extracellular matrix structural constituent (GO:0005201);phosphate transport (GO:0006817) |
9.53 | FBN1 | fibrillin 1 (Marfan syndrome) | calcium ion binding (GO:0005509);development (GO:0007275);extracellular matrix structural constituent (GO:0005201);skeletal development (GO:0001501);visual perception (GO:0007601) |
9.51 | PAM | peptidylglycine alpha-amidating monooxygenase | electron transporter activity (GO:0005489);monooxygenase activity (GO:0004497);peptide amidation (GO:0001519);peptidylglycine monooxygenase activity (GO:0004504);protein modification (GO:0006464) |
9.50 | LOC92912 | hypothetical protein LOC92912 | ligase activity (GO:0016874);ubiquitin conjugating enzyme activity (GO:0004840);ubiquitin cycle (GO:0006512);ubiquitin-protein ligase activity (GO:0004842) |
9.47 | COL6A2 | collagen, type VI, alpha 2 | cell-cell adhesion (GO:0016337);collagen (GO:0005202);extracellular matrix organization and biogenesis (GO:0030198);extracellular matrix structural constituent (GO:0005201);muscle development (GO:0007517);phosphate transport (GO:0006817);protein binding, bridging (GO:0030674) |
9.45 | PTX1 | PTX1 protein | None |
9.41 | KIAA0992 | palladin | amino acid metabolism (GO:0006520) |
9.33 | CSPG2 | chondroitin sulfate proteoglycan 2 (versican) | calcium ion binding (GO:0005509);cell adhesion (GO:0007155);chondroitin sulfate proteoglycan (GO:0005204);development (GO:0007275);glycosaminoglycan binding (GO:0005539);heterophilic cell adhesion (GO:0007157);hyaluronic acid binding (GO:0005540);lectin (GO:0005530);proteoglycan (GO:0005203);sugar binding (GO:0005529) |
9.32 | CSPG2 | chondroitin sulfate proteoglycan 2 (versican) | calcium ion binding (GO:0005509);cell adhesion (GO:0007155);chondroitin sulfate proteoglycan (GO:0005204);development (GO:0007275);glycosaminoglycan binding (GO:0005539);heterophilic cell adhesion (GO:0007157);hyaluronic acid binding (GO:0005540);lectin (GO:0005530);proteoglycan (GO:0005203);sugar binding (GO:0005529) |
9.30 | SERPINH1 | serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | collagen binding (GO:0005518);heat shock protein activity (GO:0003773);response to stress (GO:0006950);serine-type endopeptidase inhibitor activity (GO:0004867);serpin (GO:0004868) |
9.23 | TM4SF6 | transmembrane 4 superfamily member 6 | cell adhesion molecule activity (GO:0005194);cell motility (GO:0006928);positive regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043123);signal transducer activity (GO:0004871) |
9.20 | PTRF | polymerase I and transcript release factor | None |
9.19 | LATS2 | LATS, large tumor suppressor, homolog 2 (Drosophila) | ATP binding (GO:0005524);protein amino acid phosphorylation (GO:0006468);protein serine/threonine kinase activity (GO:0004674);transferase activity (GO:0016740);tumor suppressor (GO:0008181) |
9.12 | CTBP2 | C-terminal binding protein 2 | L-serine biosynthesis (GO:0006564);negative regulation of cell proliferation (GO:0008285);oxidoreductase activity (GO:0016491);oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616);tumor suppressor (GO:0008181);viral replication (GO:0008166) |
9.06 | ITGAV | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | cell adhesion (GO:0007155);cell adhesion receptor activity (GO:0004895);cell-matrix adhesion (GO:0007160);integrin-mediated signaling pathway (GO:0007229);protein binding (GO:0005515) |
9.05 | RCN2 | reticulocalbin 2, EF-hand calcium binding domain | calcium ion binding (GO:0005509);protein binding (GO:0005515);tumor suppressor (GO:0008181) |
8.98 | CPD | carboxypeptidase D | carboxypeptidase A activity (GO:0004182);carboxypeptidase D activity (GO:0004187);carboxypeptidase activity (GO:0004180);hydrolase activity (GO:0016787);proteolysis and peptidolysis (GO:0006508);zinc ion binding (GO:0008270) |
8.98 | FLJ21174 | hypothetical protein FLJ21174 | None |
8.96 | MGC5395 | hypothetical protein MGC5395 | intracellular signaling cascade (GO:0007242);neurogenesis (GO:0007399);protein binding (GO:0005515) |
8.96 | MFAP2 | microfibrillar-associated protein 2 | extracellular matrix glycoprotein (GO:0005207);extracellular matrix structural constituent (GO:0005201) |
8.94 | CRIM1 | cysteine-rich motor neuron 1 | cysteine-type endopeptidase activity (GO:0004197);insulin-like growth factor binding (GO:0005520);insulin-like growth factor receptor activity (GO:0005010);neurogenesis (GO:0007399);proteolysis and peptidolysis (GO:0006508);regulation of cell growth (GO:0001558);serine-type endopeptidase inhibitor activity (GO:0004867) |
8.92 | ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | alcohol metabolism (GO:0006066);aldehyde dehydrogenase [NAD(P)+] activity (GO:0004030);aldehyde dehydrogenase activity (GO:0004028);lipid metabolism (GO:0006629);metabolism (GO:0008152);oxidoreductase activity (GO:0016491) |
8.92 | MGC34132 | hypothetical protein MGC34132 | None |