Table 2 Domain frequency within the clustered communities. The table shows the most frequently observed domains in the metastasis-related cluster communities (observed frequencies) alongside the expected domain frequencies, based on the domain composition of the whole rat genome. The n-fold difference was calculated from the frequency percentages (numbers within parentheses).
Domain | Observed frequency (%) | Expected frequency (%) | n-fold difference |
|---|---|---|---|
Spectrin repeat | 56 (6.9) | 6 (0.7) | 8.3 |
IQ calmodulin-binding motif | 54 (6.6) | 2 (0.2) | 26.5 |
EGF-like domain | 52 (6.4) | 16 (2.0) | 2.2 |
Protein kinase domain | 47 (5.8) | 12 (1.4) | 3.0 |
SH2 domain | 27 (3.3) | 2 (0.3) | 11.7 |
EF hand | 25 (3.1) | 7 (0.8) | 2.6 |
Immunoglobulin domain | 21 (2.6) | 35 (4.3) | -0.4 |
SH3 domain | 20 (2.4) | 6 (0.7) | 2.6 |
Calponin homology (CH) domain | 13 (1.6) | 2 (0.3) | 5.4 |
Proteasome A-type and B-type | 12 (1.5) | 1 (0.1) | 20.0 |
LIM domain | 11 (1.3) | 3 (0.4) | 2.7 |
Transforming growth factor β-like domain | 10 (1.2) | 1 (0.1) | 11.2 |