Figure 12
From: Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data
Genetic Model THL ( T rait H eterogeneity with L ocus Heterogeneity). The penetrance tables for Trait I and Trait II are presented. Cell values indicate penetrance level, or the probability of having the trait, given the corresponding multilocus genotype. For Trait I, a Mendelian recessive genetic model is used, in which the trait is penetrant only when two copies of the high risk (B) allele are present. For Trait II, a locus heterogeneity model described by Li and Reich [49] is used, in which the trait is penetrant only when two copies of the high risk allele at one or both loci are present (in this case the B alleles for locus 2 and 3 are high risk).