Figure 5

A scheme of two potential scenarios of regulatory networks. Genes that separate two classes of patients are denoted by red circles and TFs by yellow circles. A) The four separating genes are localized in the network such that the (link) distance between each pair is at most three. These four genes share two regulators denoted by black bold circumferences. These two regulators are likely to be relevant for sample discrimination because they regulate the four most discriminatory genes. B) The four separating genes have remote or no regulatory linkage and therefore their regulating TFs are less likely to be helpful in sample separation.