Figure 1

Matrix of the distances between the biological relevant units of the proteins in the set. Multipole-based distance matrix calculated from Cα atoms that are part of the biologically relevant portion of the proteins in the set. The proteins in the set are identified by their pdb id. The groups inside the TPK family are labeled according to the classification produced by Manning et al. [28, 29]. In this calculations all multipoles up to l _max = 4 are retained in Eq. (7). Here, and in all other distance matrix representations, darker colors map into bigger distances. The upper six raws and left six columns represent inter-family distances while the rest of the matrix contains only distances between the kinase family members.