Table 1 C. elegans genes known to extend or shorten life span. The list is taken from the Genes database of SAGEKE http://www.sageke.org
Life span extension | |
|---|---|
Hsp-6 | heat shock 70 protein |
age-1 | inositol/phosphatidylinositol kinase; signal transduction |
age-2 | AGEing alteration |
che-2 | G-beta-repeats |
che-3 | microtubule motor, dynein ATPase; microtubule-based movement |
che-11 | abnormal CHEmotaxis |
che-13 | abnormal CHEmotaxis |
clk-1 | ubiquinone biosynthesis |
clk- 2 | CLocK (biological timing) abnormality |
clk-3 | CLocK (biological timing) abnormality |
daf-2 | transmembrane receptor protein tyrosine kinase; phosphorylation, hydrogen transport, signalling |
daf-6 | abnormal DAuer Formation |
daf-10 | abnormal DAuer Formation |
daf-12 | steroid hormone receptor; transcription regulation |
daf-19 | DNA binding transcription factor; transcription regulation |
daf-28 | abnormal DAuer Formation |
eat-1 | EATing: abnormal pharyngeal pumping |
eat-2 | EATing: abnormal pharyngeal pumping |
eat-3 | EATing: abnormal pharyngeal pumping |
eat-6 | Na+/K+ ATPase α subunit; cation transport, metabolism |
eat-13 | EATing: abnormal pharyngeal pumping |
glp-1 | calcium ion binding; cell differentiation |
gro-1 | tRNA isopentenyltransferase; tRNA processing |
ins-1 | INSulin related |
ins-18 | insulin-like growth factor I like; hormone |
isp-1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur protein; electron transport |
mec-8 | nucleic acid binding; mechanosensory |
mes-1 | protein tyrosine kinase |
osm-1 | OSMotic avoidance abnormal |
osm-3 | kinesin |
osm-5 | aspartic-type endopeptidase; proteolysis and peptidolysis |
osm-6 | N-acetyllactosamine synthase |
pdk-1 | protein serine/threonine kinase |
pgl-1 | P GranuLe abnormality |
rad-8 | RADiation sensitivity abnormal/yeast RAD-related |
sir-2.1 | DNA binding; transcription regulation, chromatin silencing |
spe-10 | defective SPErmatogenesis |
spe-26 | MIPP repeats; defective SPErmatogenesis |
tax-4 | Cyclic-nucleotide-gated olfactory channel; potassium transport |
tkr-1 | G protein coupled receptor; signalling |
unc-4 | homeobox protein (otd subfamily); transcription regulation |
unc-13 | intracellular signaling cascade |
unc-26 | inositol/phosphatidylinositol phosphatase |
unc-31 | PH (pleckstrin homology) domain |
unc-32 | TJ6/proton pump |
unc-64 | syntaxin |
unc-76 | UNCoordinated |
Shortened life span | |
ctl-1 | CaTaLase |
daf-16 | transcription factor |
eat-7 | EATing: abnormal pharyngeal pumping |
fer-15 | FERtilization defective (abnormal sperm) |
mev-1 | Succinate dehydrogenase cytochrome b chain; electron transport, tricarboxylic acid cycle |