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Figure 1 | BMC Bioinformatics

Figure 1

From: Genome-wide prediction of transcriptional regulatory elements of human promoters using gene expression and promoter analysis data

Figure 1

Schematic diagram of the procedures used in this study. Gene expression data sets were retrieved from GEO. Human promoters with experimentally verified transcription start sites were retrieved from the DBTSS database and analyzed for TFBSs with the TransFac version 3.0 database using the MatInspector program. For each microarray data set, the fold-change values between two experimental groups were calculated and used in gene set analyses with gene sets of TFBSs. This procedure was repeated over multiple data sets, resulting in a matrix of fold-change values over multiple data sets and a matrix of Z-scores over multiple data sets. The correlations between fold-change values and Z-scores over multiple data sets were calculated. Finally, statistically significant TFBSs were identified for each gene.

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BMC Bioinformatics

ISSN: 1471-2105

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