Figure 1

SimTriplex logic interactions chart. Vaccine Cells (VC) produce interleukin 12 (IL-12) and release Tumor Associated Antigens (TAA) when they die either spontaneously or as a consequence of cytotoxic T cell (TC) lysis upon recognition of allogeneic MHC on VC. TAA interact with antigen presenting cells (APC), i.e. macrophages (MP), dendritic cells (DC) and B cells, which internalize TAA and become able to stimulate helper T cells (TH). A TH↔B interaction induces differentiation of B cells into plasma cells (PLB) which produce antibodies (Ab) recognizing cancer cells (CC). IL-12 enhances the effectiveness of Natural Killer (NK) and TC against CC. The final state is that CC are controlled by immune responses activated by VC. All the interactions embed a probabilistic rule which depends on biological affinity or other factors.