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Table 4 47 genes down-regulated in tumoral tissue, comparing normal mucosa to matched tumor colon tissue.

From: On the statistical assessment of classifiers using DNA microarray data

Function Gene OMIM Accession no. p-value Gene description
Apoptosis PDCD4 608610 NM_014456.1 0.032 Programmed cell death 4 (neoplastic transformation inhibitor)
  FAS 604306 NM_000043.1 0.044 Fas (TNF receptor superfamily, member 6)
  CASP7 601761 NM_001227.1 0.050 Caspase 7, apoptosis-related cysteine protease
Transport SLC30A10   NM_018713.1 0.036 Solute carrier family 30, member 10 (zinc transport?)
  SLC9A2 600530 AF073299.1 0.041 Solute carrier family 9 (sodium/hydrogen exchanger), member 2
  SLC4A4 603345 AF069510.1 0.041 Solute carrier family 4, sodium bicarbonate cotransporter, member 4
  SLC26A3 126650 NM_000111.1 0.044 Solute carrier family 26, member 3
  SLC26A2 606718 AI025519 0.044 Solute carrier family 26 (sulfate transporter), member 2
  SGK2 607589 NM_016276.1 0.038 Serum glucocorticoid regul. kinase 2 (potassium channel activation)
  KIF5C 604593 NM_004522.1 0.040 Kinesin family member 5C (intracellu-lar transport)
  KIF13B 607350 NM_015254.1 0.046 Kinesin family member 13B (intracel-lular transport)
  VAPA 605703 AF154847.1 0.047 VAMP (vesicle-associated membrane protein)-assoc. protein A,33 kDa
Signalling MAP2K4 601335 NM_022129.1 0.033 Mitogen-activated protein kinase kinase 4 (MAPK signaling pathway)
  RPS6KA5 603608 AF074393.1 0.040 Ribos. prot. S6 kinase, 90 kDa, polyp. 5(MAPK signalling pathway)
  MEF2C 600662 L08895.1 0.033 MADS box transcr. enhancer factor 2, (MAPK signalling pathway)
  PPP2R3A 604944 NM_002718.1 0.037 Protein phosphatase 2, regulatory sub-unit B, alpha (Wnt signalling)
  PDE9A 602973 NM_002606.1 0.040 Phosphodiesterase 9A (signal transduc-tion)
  PPAP2A 607124 AF014403.1 0.042 Phosphatidic acid phosphatase type 2A (signal transduction)
  MUC4 158372 AJ242547.1 0.044 Mucin 4 (Erb2 signalling pathway)
  DSCR1 602917 AL049369.1 0.045 Down syndrome critical region gene 1 (signal transduction)
  SHOC2 602775 NM_007373.1 0.046 Soc-2 suppressor of clear homolog (MAPK signaling pathway)
  SOCS2 605117 NM_003877.1 0.049 Suppressor of cytokine signaling 2 (GH/IGF1 signaling pathway)
  SMAD2 601366 NM_005901.1 0.049 SMAD, homolog 2 (Drosophila) (TGF-beta_signaling)
Cell-surface signalling TSPAN7 300096 NM_004615.1 0.036 Tetraspanin 7
  EDG2 602282 NM_001401.1 0.041 Lysophosphatidic acid G-protein-coupled receptor, 2
  TMPRSS2 602060 AF270487.1 0.046 Transmembrane protease, serine 2
  CEACAM7   NM_006890.1 0.047 Carcinoembryonic antigen-related cell adhesion molecule 7
Cell adhesion DSC2 125645 NM_004949.1 0.045 Desmocollin 2
Cell differentiation NDRG2 605272 NM_016250.1 0.038 NDRG family member 2
  EPB41L3 605331 NM_012307.1 0.044 Erythrocyte membrane protein band 4.1-like 3 (suppressor gene?)
  MTUS1 609589 NM_024307.1 0.045 Mitochondrial tumor suppressor 1
Metabolism HMGCL 246450 NM_000191.1 0.040 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
  UGDH 603370 NM_003359.1 0.041 UDP-glucose dehydrogenase
  CA12 603263 NM_001218.2 0.044 Carbonic anhydrase XII
  CA2 259730 NM_000067.1 0.049 Carbonic anhydrase II
  CA4 114760 NM_000717.2 0.050 Carbonic anhydrase IV
  CA1 114800 NM_001738.1 0.050 Carbonic anhydrase I
  CA7 114770 NM_005182.1 0.050 Carbonic anhydrase VII
  HPGD 601688 U63296.1 0.046 Hydroxyprostaglandin dehydrogenase 15-(NAD)
  FUCA1 230000 NM_000147.1 0.047 Fucosidase, alpha-L-1, tissue
  ACAT1 607809 NM_000019.1 0.048 Acetyl-Coenzyme A acetyltransferase 1
  ADH1C 103730 NM_000669.2 0.048 Alcohol dehydrogenase3 (class I), gamma polypeptide
  AQP8 603750 NM_001169.1 0.050 Aquaporin 8
Cell growth FAM107A 608295 NM_007177.1 0.040 Family with sequence similarity 107, member A (TU3A)
  EMP1 602333 NM_001423.1 0.047 Epithelial membrane protein 1 (growth arrest)
  BTG1 109580 NM_00173 1.1 0.050 B-cell translocation gene 1, anti-proliferative
  KLF4 602253 NM_004235.1 0.050 Kruppel-like factor 4 (gut)