Table 1 Attributes used for predicting functional effects of missense mutations
From: Predicting the effect of missense mutations on protein function: analysis with Bayesian networks
Abbreviation | Type | Description | Information |
|---|---|---|---|
effect | Discrete | Effect of mutation on functionality | Class |
ac | Continuous | Solvent accessible area of native AA | |
rac | Continuous | Accessibility relative to maximum accessibility in training set | |
bf | Continuous | Normalised B-factor of native AA | |
nbf | Continuous | Normalised B-factor of structural neighbourhood of native AA | Structural |
bur | Discrete | Mutant AA is charged AA at buried site | |
trn | Discrete | Mutant AA occurs at glycine or proline in a turn | |
hlx | Discrete | Mutant AA occurs in helical region and involves glycine or proline | |
ifc | Discrete | Native AA is near subunit interface | |
nrent | Continuous | Phylogenetic entropy of structural neighbourhood of native AA | Structural + Evolutionary |
rent | Continuous | Normalised phylogenetic entropy of native AA | |
cnsd | Discrete | Native AA is at conserved position in phylogenetic profile | |
ncnsd | Discrete | Native AA is near conserved position in phylogenetic profile | Evolutionary |
uslaa | Discrete | Mutant AA is not in phylogenetic profile | |
uslby | Discrete | Mutant AA is not in the smallest AA class that includes the phylogenetic profile |