Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis

Table 6 Functional characterization of fragile sites' connected components.

GO id	GO term description	Cluster	-Log₁₀ (p value)
			α = 1%	α = 5%	α = 10%
GO:0005126	hematopoietin/interferon-class	A₁, A₅, ABC₁₀	15.090	15.408	11.807
	(D200-domain) cytokine receptor	A₁, A₅, ABC₁₀
GO:0005132	interferon-alpha/beta receptor binding	A₁, A₅, ABC₁₀	12.394	11.902	9.704
GO:0009615	response to virus	A₁, A₅, ABC₁₀	11.857	10.889	6.811
GO:0005125	cytokine activity	A₁, A₅, ABC₁₀	6.252	5.843	4.919
GO:0005615	extracellular space	A₁, A₅	5.390	4.627	< threshold
GO:0042272	nuclear RNA export factor complex	A₁, A₅	4.713	4.538	< threshold
GO:0005515	protein binding	A₁	4.698	< threshold	< threshold
GO:0008320	protein carrier activity	ABC₁₀	< threshold	< threshold	4.645
GO:0004091	carboxylesterase activity	B₁, B₅	7.133	7.133	_
GO:0004759	serine esterase activity	B₁, B₅	7.133	7.133	_
GO:0006805	xenobiotic metabolism	B₁, B₅	4.038	4.038	_
GO:0003700	transcription factor activity	D₁₀	_	_	5.853
GO:0030528	transcription regulator activity	D₁₀	_	_	4.758
GO:0003676	nucleic acid binding	D₁₀	_	_	4.149

Overrepresented GO terms are reported along with their Gene Ontology identifiers, full descriptions, enriched connected component(s) for those GO terms and negative logarithm of their hypergeometric p-values.

ISSN: 1471-2105