Table 7 KEGG pathways for genes annotated to overrepresented fragile sites.

MAPK signaling pathway

Notch signaling pathway

Wnt signaling pathway

Calcium signaling pathway

TGF-beta signaling pathway

PLA2G3

MAP3K13

JAG1

DVL3

SENP2

TCF7

DVL3

PDE1A

SMAD5

Jak-STAT signaling pathway:

IFNA1

IFNA2

IFNA4

IFNA5

IFNA6

IFNA8

IFNA10

IFNA14

IFNA17

IFNA21

IFNB1

IFNK

IFNW1

LIF

OSM

EPO

L12RB2

Signaling molecules and interactions:

ECM-receptor interaction

Cell adhesion molecules (CAMs)

Neuroactive ligand-receptor interaction

LAMC2

LAMC1

ITGAV

ITGAV

VCAM1

NEGR1

SST

Cytokine-cytokine receptor interaction:

IFNA1

IFNA2

IFNA4

IFNA5

IFNA6

IFNA8

IFNA10

IFNA14

IFNA17

IFNA21

IFNB1

IFNK

IFNW1

LIF

OSM

EPO

TNFSF4

TNFSF18

L12RB2

MET

Immune system:

Natural killer cell-mediated cytotoxicity

Leukocyte transendothelial migration

Complement-coagulation cascades

IFNA1

IFNA2

IFNA4

IFNA5

IFNA6

IFNA8

NCF2

VCAM1

PLG SERPINC1 SERPINE1 KNG1

Toll-like receptor signaling pathway

T/B cell receptor signaling pathway

IFNA1

IFNA2

IFNA4

IFNA5

IFNA6

IFNA8

IFNA10

IFNA14

IFNA17

IFNA21

IFNB1

BCL10

Cell motility and comunication:

Focal adhesion

Adherens junction

Tight junctin

Regulation of actin cytoskeleton

TNR

LAMC2

MET

LAMC1

ITGAV

MET

INADL

ITGAV

NCKAP1

LIMK2

Cell growth and death:

cell cycle

Apoptosis

CDC7

CDKN2A

FASLG

Genetic information processing:

SNARE interactions in vesicular transport

Basal transcription factors

Ribosome

RNA polymerase

Proteasome

SNAP25

STX6

TAF1L

GTF2B

RPL5

POLR2H

NBEA

Lipid metabolism:

Nucleotide metabolism:

Xenobiotic metabolism:

Glycan metabolim:

Glycerophospholipid metabolism

Purine

Pyramidine

by cytochrome P450

Glycosphingolipid metabolism

DBT

PLA2G3

ACHE

PDE1A

POLR2H

POLR2H

CYP3A43

SMPD3