Grouping Gene Ontology terms to improve the assessment of gene set enrichment in microarray data

BMC Bioinformatics

Table 6 POSOC membership for top FatiGO terms for the Cd36 data set.

FatiGO Rank: GO node	Membership of POSOC groups	POSOC group significant at 5%?
1: response to external stimulus	IA
2: response to pest, pathogen or parasite	response to pest, pathogen or parasite	yes
3: response to wounding	response to wounding	yes
4: organismal movement	IA
5: response to biotic stimulus	IA
6: neurophysiological process	-
7: response to stress	IA
8: inflammatory response	immune response	yes
	response to pest, pathogen or parasite	yes
	response to wounding	yes
9: transmission of nerve impulse	-
10: neuromuscular physiological process	-
11: defense response	IA
12: immune response	immune response	yes
	response to pest, pathogen or parasite	yes
	response to wounding	yes
13: chemotaxis	immune response	yes
	response to pest, pathogen or parasite	yes
	cell migration	no
	chemotaxis	no
	response to wounding	yes
14: nucleobase, nucleoside, nucleotide and nucleic acid metabolism	-
15: cell-cell signalling	-

POSOC group membership of the most over-represented GO terms found by FatiGO. "IA" in the membership column indicates the term is an immediate ancestor (IA) of one of the significant POSOC groups. Note that none of these terms were found significant by the FatiGO analysis.

ISSN: 1471-2105