Figure 2

Biases in the parametric binary segmentation method for detection of putative enrichment sites-I. pScore distribution across 43 consecutive probes in three different biological (B₁-B₃) replicates, are shown. Probes belonging to B₁ (black) and B₂ (red) pass the pScore threshold of 50 while those belonging to B₃ (blue) fail by a significant margin. The trend in the pScore distribution hints at potential enrichment but if B₃ were the only dataset available a false negative bias could have been introduced in the analysis.