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Table 8 Cellular compartments for protein with CB regions with different D values (*)

From: Exhaustive assignment of compositional bias reveals universally prevalent biased regions: analysis of functional associations in human and Drosophila

HUMAN

       

Overall

#

      

GO:0005634

954/4618† (10 -63 )

      

Nucleus

       

GO:0005737

224/4618† (10 -5 )

      

Cytoplasm

       

GO:0016020238/4618

       

Membrane

       

D ≤ 0.25

#

0.25 < D ≤ 0.5

#

0.5 < D ≤ 0.75

#

D > 0.75

#

GO:0005634

137/980

GO:0005634

206/867† (10-18)

GO:0005634

167/758† (10-11)

GO:0005634

196/948† (10-10)

Nucleus

 

Nucleus

 

Nucleus

 

Nucleus

 

GO:0005737

38/980

GO:0005737

35/867

GO:0005737

37/758

GO:0005737

98/948†(10-19)

Cytoplasm

 

Cytoplasm

 

Cytoplasm

 

Cytoplasm

 

GO:0016020

68/980

GO:0016020

29/867

GO:0016020

31/758

GO:0016020

34/948

Membrane

 

Membrane

 

Membrane

 

Membrane

 

FRUITFLY

       

Overall

#

      

GO:0005634

593/2972† (10 -62 )

      

Nucleus

       

GO:0005737

141/2972

      

Cytoplasm

       

GO:0016020

49/2972

      

Membrane

       

D ≤ 0.25

#

0.25 < D ≤ 0.5

#

0.5 < D ≤ 0.75

#

D > 0.75

#

GO:0005634

65/372† (10-2)

GO:0005634

120/556 † (10-14)

GO:0005634

168/678† (10-27)

GO:0005634

270/1143† (10-10)

Nucleus

 

Nucleus

 

Nucleus

 

Nucleus

 

GO:0005737

20/372

GO:0005737

19/556

GO:0005737

38/678

GO:0005737

65/1143† (10-20)

Cytoplasm

 

Cytoplasm

 

Cytoplasm

 

Cytoplasm

 

GO:0016020

6/372

GO:0016020

12/556

GO:0016020

7/678

GO:0016020

16/1143

  1. (*) The numbers of CB regions (overall, and for four categories split up according to D value) that have the GO term annotation for Nucleus, Cytoplasm and Membrane are counted up.
  2. Significant overrepresentation using binomial statistics (P' < 0.05), corrected for multiple hypothesis testing over cellular compartment GO terms. P' values are indicated in brackets, rounded up to the nearest power of ten.