Figure 4

Optimized solution spaces for biomass and lysine synthesis rates in C. glutamicum for varying ammonia and oxygen uptake rates. The uptake rate of glucose was fixed at 100 moles/Lh. The choice of the objective function was maximization of biomass. (a) shows the biomass synthesis rates at various ammonia and oxygen consumption rates. The numbered points represent, 1: (155, 127, 0); 2: (365, 67, 0); 3: (220, 40, 0); 4: (192, 51, 69); 5: (256, 69, 94); 6: (146, 91, 124) in the order given by oxygen and ammonia uptake rates and biomass formation rate, respectively. (b) shows the lysine synthesis rates at various ammonia and oxygen consumption rates. The numbered points indicate, 1: (155, 127, 63.5); 2: (365, 67, 33.5); 3: (220, 40, 20); 4: (192, 51, 0); 5: (256, 69, 0); 6: (146, 91, 0) in the order given by oxygen uptake rate, ammonia uptake rate and lysine formation rate, respectively. The experimental values were reported by Vallino [18] at 11.5 h, 13.5 h and 15.8 h and were plotted onto the graph. '○' indicates experimental data at 11.5 h; '□' indicates experimental data at 13.5 h and '△'indicates experimental data at 15.8 h.