Figure 3

Results from the Core Modules of ProFAT. (A) Graphical and tabular representation of results from the Annotation Engine and Threading Engine (Dip13α/APPL1 [GenBank:NP_036228] was used as a query). Red bars in the image represent identified database sequences that contain one or more keywords from the user-provided list in their annotation, blue bars represent sequences where no keywords were detected. The upper bars show results from the Annotation Engine, the lower bars those from the Threading Engine. The table below the image gives the user the number of hits with and without keywords, links to the raw results, tabular information on the frequency of observed GO-terms, as well as the starting and ending residue of the region and conserved domains in the input query. The numbers in the column 'Keyword Hits' link to the annotated alignments of keyword-positive database entries. Moving the mouse over the respective number changes the format of the graph to the image seen in (B), whereby alignments are represented by narrow lines. The number in 'Total Hits' links to the complete PSI-BLAST output, whereby each alignment is annotated with the associated information of the database hit. (B) Graphical output of the region 1 – 280 of the input query from the Annotation Engine. (C) Representative alignment of one of the identified hits that shows biological relevance next to sequence similarity. Each sequence that has been identified by PSI-BLAST is annotated with associated GenBank features, PubMed abstracts and Gene Ontology terms, as well as its sequence. Associated information can be individually viewed by clicking on the '+' sign next to the respective information.