Figure 1

Response of the network to an increase in external glucose concentration. a) First five minutes, a "rapid sampling" experiment (black) and the simulation of the same perturbation with linlog kinetics (blue) using the elasticities estimated from the experimental data from dynamic perturbation. b) Long term response of the cells to the glucose pulse. The time is presented in minutes; intracellular metabolites are given in μ mol gDW^-1; extracellular metabolites are given in mM.