Figure 9

gFWER reference distribution ( k = 10) for HDLC. The genome-wide bootstrap approach outlined in Figure 8 is used to generate a distribution of background association score profiles. Here, we show the background distribution for k = 10. For computational efficiency, at each combination of SNP window and bootstrap sample, association scores less than 2.5 are set at an upper bound of 2.5 (reducing the number of bootstrap iterations required in Figure 6). The black line shows the cumulative distribution of association scores. The vertical red line is the αg 0.05 percentile of these 10,000 values and is set at the gFWER threshold (k = 10). For visualization, the blue bars show the raw frequency values, and the yellow bars show a 100 × magnification.