Table 3 "DNA damage response" related GO terms that are differentially represented between oocyte and preimplantation with respect with common reference tissues. Pairwise comparisons of oocyte and preimplantation dbEST libraries to eight reference libraries revealed five GO terms related to the biological process of "DNA damage response": GO:0006974 ("response to DNA damage stimulus"), GO:0042770 ("DNA damage response, signal transduction"), GO:0000077 ("DNA damage checkpoint"), GO:0003684 ("damaged DNA binding") and GO:0006281 ("DNA repair"). GO terms with EST Coverage Ratio >= 1.5 or <= 1/1.5 and with corrected P_value of 0.1 were selected.
From: GO-Diff: Mining functional differentiation between EST-based transcriptomes
| Â | GO ID | Oocyte (dbEST 1389) | 2-cell to 16-cell Embryos (dbEST 1381,1382,1524,1532) | ||
|---|---|---|---|---|---|
| Â | Â | EST Coverage Ratio (Other tissue/Oocyte) | Corrected P _value | EST Coverage Ratio (Other tissue/Embryos) | Corrected P _value |
Liver (dbEST 1299) | GO:0006974 | 9.0E-02 | 2.5E-38 | 0.15 | 7.9E-29 |
| Â | GO:0042770 | 5.6E-02 | 3.2E-04 | 6.5E-02 | 4.3E-05 |
| Â | GO:0000077 | 1.4E-02 | 1.4E-05 | 3.8E-02 | 7.5E-05 |
| Â | GO:0003684 | 1.2E-04 | 2.0E-02 | 5.0E-02 | 3.4E-07 |
| Â | GO:0006281 | 9.7E-02 | 1.4E-30 | 0.19 | 4.0E-20 |
Brain (dbEST 1469) | GO:0006974 | 0.29 | 4.8E-06 | 0.58 | 6.4E-02 |
| Â | GO:0042770 | 0.12 | 5.6E-02 | - | - |
| Â | GO:0000077 | 0.12 | 5.6E-02 | - | - |
| Â | GO:0003684 | - | - | - | - |
| Â | GO:0006281 | 0.30 | 6.5E-05 | - | - |
Kidney (dbEST 1764) | GO:0006974 | 0.30 | 6.4E-09 | 0.35 | 1.0E-04 |
| Â | GO:0042770 | 0.0 | 7.0E-03 | - | - |
| Â | GO:0000077 | 0.0 | 7.0E-03 | - | - |
| Â | GO:0003684 | - | Â | 0.0 | 7.0E-02 |
| Â | GO:0006281 | 0.21 | 1.4E-06 | 0.40 | 9.1E-03 |
Placenta (dbEST 1783) | GO:0006974 | 6.2E-02 | 1.6E-15 | 0.12 | 9.1E-08 |
| Â | GO:0042770 | 6.6E-02 | 1.6E-02 | - | - |
| Â | GO:0000077 | 0.0 | 3.8E-03 | 0 | 9.9E-02 |
| Â | GO:0003684 | 0.0 | 8.7E-02 | 0.0 | 4.7E-02 |
| Â | GO:0006281 | 3.7E-02 | 1.7E-14 | 7.1E-02 | 1.0E-07 |
Skin (dbEST 498) | GO:0006974 | 0.33 | 1.1E-07 | 0.65 | 2.7E-02 |
| Â | GO:0042770 | - | - | - | - |
| Â | GO:0000077 | - | - | - | - |
| Â | GO:0003684 | - | - | - | - |
| Â | GO:0006281 | 0.28 | 4.7E-08 | 0.55 | 2.5E-03 |
Testis (dbEST 483) | GO:0006974 | 0.28 | 1.4E-05 | 0.57 | 9.0E-02 |
| Â | GO:0042770 | 6.8E-02 | 4.1E-02 | - | - |
| Â | GO:0000077 | 6.8E-02 | 4.1E-02 | - | - |
| Â | GO:0003684 | Â | - | - | - |
| Â | GO:0006281 | 0.33 | 4.6E-04 | - | - |
Heart (dbEST 509) | GO:0006974 | 0.33 | 1.4E-06 | 0.65 | 7.6E-02 |
| Â | GO:0042770 | Â | Â | Â | - |
| Â | GO:0000077 | 0.14 | 3.7E-02 | Â | - |
| Â | GO:0003684 | Â | Â | Â | - |
| Â | GO:0006281 | 0.34 | 3.1E-05 | Â | - |
Lung (dbEST 526) | GO:0006974 | 0.24 | 2.2E-06 | 0.48 | 2.3E-02 |
| Â | GO:0042770 | - | - | - | - |
| Â | GO:0000077 | - | - | - | - |
| Â | GO:0003684 | - | - | - | - |
| Â | GO:0006281 | 0.21 | 5.2E-06 | 0.40 | 1.4E-02 |