GONOME and GOstat output on random positions. Panel A compares GONOME and GOstat analyses of 30,000 randomly selected positions in the human genome. The E-values of the top 10 over-represented GO Terms as found by GOstat (red), and the values GONOME derives for the same terms (blue). Panel B shows the top ten over-represented terms according to GONOME. E-values were calculated as described in Methods.