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Table 2 Over and under-represented sites in in TNFα expression data. Predicted sites that are significantly over-represented (Ratio [FC>2.0] > 1.4) and under-represented (Ratio [FC>2.0] < 0.7) in the promoters of genes that are differentially expressed in primary human endothelial cells upon TNFα stimulation

From: Beyond microarrays: Finding key transcription factors controlling signal transduction pathways

Matrix ID in TRANSFAC®

Ratio [FC>2.0]

#sites k

#sites m

p-value

Ratio [FC>2.5]

Ratio [FC>3.0]

V$NFKAPPAB65_01

5.54

36

7

1.45·10-6

10.44

12.49

V$CREL_01

3.29

58

19

1.04·10-6

4.83

5.52

V$CDX2_Q5

2.45

41

18

7.35·10-4

2.90

2.74

V$IRF_Q6

1.88

68

39

9.46·10-4

-

-

V$AP1_01

2.09

35

18

6.51·10-3

2.55

2.78

V$FOXJ2_02

1.58

94

64

2.70·10-3

1.61

1.78

V$MAZ_Q6

1.45

284

211

2.32·10-5

-

-

V$GATA4_Q3

1.58

139

95

3.50·10-4

2.54

2.69

V$CETS1P54_01

0.20

6

32

3.19·10-5

0.38

0.50

V$YY1_02

0.30

12

43

5.21·10-5

0.25

-

V$USF_02

0.38

18

50

2.15·10-4

0.36

0.39

V$CREBATF_Q6

0.61

65

114

9.35·10-4

-

-

V$E2F_Q3_01

0.63

88

149

4.13·10-4

0.36

0.28

V$MYC_Q2

0.64

87

145

7.05·10-4

0.45

0.50

  1. k and m – numbers of sites computed in A and B sets respectively. p-value is computed according to the eq. 2.