Metal-Binding Protein Classes | Training set | Testing set | Independent evaluation set | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | positive | negative | positive | negative | positive | negative | Q(%) | ||||||
 |  |  | TP | FN | TN | FP | TP | FN | SE(%) | TN | FP | SP(%) |  |
Calcium-binding | 1816 | 4389 | 2055 | 245 | 8039 | 1906 | 1130 | 180 | 86.3% | 6373 | 851 | 88.2% | 87.9% |
Cobalt-binding | 568 | 2151 | 456 | 2 | 13407 | 10 | 360 | 81 | 81.6% | 7809 | 7 | 99.9% | 98.9% |
Copper-binding | 652 | 1999 | 417 | 109 | 13115 | 270 | 390 | 77 | 83.5% | 7587 | 146 | 98.1% | 97.3% |
Iron-binding | 3128 | 3428 | 4869 | 290 | 3992 | 675 | 1104 | 71 | 94.0% | 6328 | 598 | 91.4% | 91.7% |
Magnesium-binding | 2583 | 4023 | 2307 | 594 | 7267 | 115 | 3412 | 792 | 81.2% | 5848 | 805 | 87.9% | 85.3% |
Manganese-binding | 1608 | 3099 | 1146 | 217 | 10841 | 1086 | 1061 | 182 | 85.4% | 7148 | 415 | 94.5% | 93.2% |
Nickel-binding | 407 | 2001 | 95 | 2 | 13576 | 138 | 156 | 45 | 77.6% | 7816 | 65 | 99.2% | 98.6% |
Potassium-binding | 408 | 1845 | 489 | 10 | 13789 | 8 | 301 | 32 | 90.4% | 7847 | 4 | 99.9% | 99.6% |
Sodium-binding | 777 | 2010 | 338 | 1 | 13591 | 30 | 410 | 41 | 90.9% | 7831 | 11 | 99.9% | 99.4% |
Zinc-binding | 2731 | 6416 | 6610 | 569 | 5931 | 360 | 4616 | 1546 | 74.9% | 6289 | 127 | 98.0% | 86.7% |
All metal-binding | 5013 | 3101 | 11806 | 1015 | 4217 | 522 | 12070 | 3391 | 78.1% | 4529 | 617 | 88.0% | 80.6% |