Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris

Table 5 Preferred binding registers of experimentally determined Dsg3 peptides for PV implicated alleles.

Peptide	Allele	Sequence	Peptide	Allele	Sequence
Dsg3 78–94	DRB1*0402	QATQKITYRIS GVGIDQ	Dsg3 250–266	DRB1*0402	QCECNIKVKDV NDNFPM
	DQB1*0503	QATQKITYRISGV GIDQ		DQB1*0503	QCECNIKVKDVNDNFP M
Dsg3 96–112	DRB1*0402	PFGIFVVDKNTGD INIT	Dsg3 251–265	DRB1*0402	CECNIKVKDV NDNFP
	DQB1*0503	PFGIFVVDKNTGDIN IT		DQB1*0503	CECNIKVKDVNDNFP
Dsg3 161–177	DRB1*0402	IFMGEIEENSASNSL VM	Dsg3 342–356	DRB1*0402	SVKLSIAVKNKAE FH
Dsg3 189–205	DRB1*0402	HLNSKIAFKI VSQEPAG	Dsg3 342–358	DRB1*0402	SVKLSIAVKNKA EFHQS
	DQB1*0503	HLNSKIAFKI VSQEPAG		DQB1*0503	SVKLSIAVKNKAEF HQS
Dsg3 190–204	DRB1*0402	LNSKIAFKIVSQ EPA	Dsg3 376–392	DQB1*0503	NVREGIAFRPAS KTFTV
	DQB1*0503	LNSKIAFKIVSQ EPA	Dsg3 380–396	DRB1*0402	GIAFRPASKTFT VQKGI
Dsg3 191–205	DRB1*0402	NSKIAFKIVSQEPA G	Dsg3 483–499	DRB1*0402	VRVPDFNDNCPTAV LEK
Dsg3 205–221	DRB1*0402	GTPMFLLSRNTGEVR TL	Dsg3 762–776	DRB1*0402	QSGTMRTRHSTGGT N
	DQB1*0503	GTPMFLLSRNTGEVRT L	Dsg3 786–800	DRB1*0402	MNFLDSYFSQKAFAC
Dsg3 206–220	DRB1*0402	TPMFLLSRNTGE VRT	Dsg3 810–824	DRB1*0402	NDCLLIYDNEG ADAT
	DQB1*0503	TPMFLLSRNTGEVR T	Dsg3 963–977	DRB1*0402	ERVICPISSVPGNLA
Dsg3 210–226	DRB1*0402	LLSRNTGEVRTL TNSL

Preferred binding registers of experimentally determined Dsg3 peptides for PV implicated alleles. Best fitting registers with lowest predicted binding energies are in bold, underlined text.

ISSN: 1471-2105