Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

BMC Bioinformatics

Table 2 Distribution of different tissue/function-specific TF groups among AMP families

	Tissue/function-specific TF groups												Cut-Off [%]
	AD	NHR	CC	IMM	LIV	LUNG	MUS	NS	PAN	PIT	EYE	BS
Total no. of motifs	131	139	97	122	141	122	78	143	77	74	1	12
No. of AMPcg families	17	18	8	14	19	16	4	17	5	5	0	0	25
	14	12	7	11	14	10	4	15	3	2	0	0	30
	8	11	3	6	10	5	2	11	2	1	0	0	35
	4	7	3	4	3	4	1	9	0	0	0	0	40

Tissue/function-specific TF groups are AD: adipocyte-related TFs; NHR: nuclear hormone receptor TFs; CC: cell cycle-related TFs; IMM: immune cell-specific TFs; LIV: liver cell-specific TFs; LUNG: lung cell-specific TFs; MUS: muscle cell-specific TFs; NS: nervous system-related TFs; PAN: pancreatic B-cell related; PIT: pituitary gland-specific TFs; Eye: eye-specific TFs; BS: bone-specific TFs. TF that groups (AD, NHR etc.) occur with highest frequency among AMP families are underlined. Cut-off indicates the minimum percentage of motifs in a TF family that can bind TFs from a particular tissue/function-specific group.

ISSN: 1471-2105