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Table 2 Distribution of different tissue/function-specific TF groups among AMP families

From: Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes

  Tissue/function-specific TF groups Cut-Off [%]
  AD NHR CC IMM LIV LUNG MUS NS PAN PIT EYE BS  
Total no. of motifs 131 139 97 122 141 122 78 143 77 74 1 12  
No. of AMPcg families 17 18 8 14 19 16 4 17 5 5 0 0 25
  14 12 7 11 14 10 4 15 3 2 0 0 30
  8 11 3 6 10 5 2 11 2 1 0 0 35
  4 7 3 4 3 4 1 9 0 0 0 0 40
  1. Tissue/function-specific TF groups are AD: adipocyte-related TFs; NHR: nuclear hormone receptor TFs; CC: cell cycle-related TFs; IMM: immune cell-specific TFs; LIV: liver cell-specific TFs; LUNG: lung cell-specific TFs; MUS: muscle cell-specific TFs; NS: nervous system-related TFs; PAN: pancreatic B-cell related; PIT: pituitary gland-specific TFs; Eye: eye-specific TFs; BS: bone-specific TFs. TF that groups (AD, NHR etc.) occur with highest frequency among AMP families are underlined. Cut-off indicates the minimum percentage of motifs in a TF family that can bind TFs from a particular tissue/function-specific group.