Examined tissue | Best log10(P) | C.R. | Selected muscle motifs |
|---|
Muscle, abdominal | -2.02 | 0.43 | MEF2, SRF |
| | -2.02 | 0.42 | MYF, SRF |
Muscle, right calf | -3.75 | 0.52 | MEF2, SP1, SRF |
- We used upstream sequences and expression levels of muscle-specific transcripts [24] to see if the tool can select a motif combination composed of motifs (MEF2, MYF, SP1, SRF, and TEF) involved in muscle-specific expression from all JASPAR [18] motifs. We employed MARS as the regression method. We evaluated the results based on P values of the hypergeometric test (see the text). "Examined tissue" indicates tissues that the study [24] examined as tissues of skeletal muscle. We list here results on a motif combination(s) with the best P value among a dozen of the top motif combinations selected by the tool. "Log10(P)" indicates log10 of the P values. "C.R." indicates the contribution rate, which is the proportion of the variance of input expression levels explained by the scores of a motif combination. "Selected muscle motifs" indicates muscle-related motifs that were included in the motif combination selected by the tool.
