Flexible mapping of homology onto structure with Homolmapper

BMC Bioinformatics

Table 3 Scoring algorithms for assessing mutations by type

Mutation Type	Reported Score
substitution	percent sequences having the mutant amino acid at the mutated position
deletion	percent sequences lacking an amino acid at the mutated position
insertion	percent sequences having an amino acid at the mutated position
N-terminal truncation	percent sequences with no amino acids at or N-terminal to the mutated position
C-terminal truncation	percent sequences with no amino acids at or C-terminal to the mutated position
frameshift	percent sequences with no amino acids at or C-terminal to the mutated position
unknown	percent sequences having the wild-type residue of the mutated protein at the mutated position

To provide a crude assessment of whether a given mutation might be tolerated, homolmapper can evaluate the alignment depending on the type of the mutation, as shown here. Scores are reported as percentages in the SegID field of the output file. The type of mutation is defined by the user as part of defining the mutation.

ISSN: 1471-2105