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Table 3 Scoring algorithms for assessing mutations by type

From: Flexible mapping of homology onto structure with Homolmapper

Mutation Type Reported Score
substitution percent sequences having the mutant amino acid at the mutated position
deletion percent sequences lacking an amino acid at the mutated position
insertion percent sequences having an amino acid at the mutated position
N-terminal truncation percent sequences with no amino acids at or N-terminal to the mutated position
C-terminal truncation percent sequences with no amino acids at or C-terminal to the mutated position
frameshift percent sequences with no amino acids at or C-terminal to the mutated position
unknown percent sequences having the wild-type residue of the mutated protein at the mutated position
  1. To provide a crude assessment of whether a given mutation might be tolerated, homolmapper can evaluate the alignment depending on the type of the mutation, as shown here. Scores are reported as percentages in the SegID field of the output file. The type of mutation is defined by the user as part of defining the mutation.