Figure 8

On top, the JASPAR predictions on the human-mouse-chicken-zebrafish promoters of the Actin α -cardiac gene (ACTC, GENBANK: M13483 and M26773, RefSeq: NM 001031229 and NM 214784), the resulting MMA and the experimental evidence. At bottom, the JASPAR predictions on the human-mouse-chicken-zebrafish promoters of the Myoglobin gene (MB, GENBANK: X00371, RefSeq: NM 013593, NM 203377 and NM 200586), the resulting MMA and the experimental evidence. In both cases, the TF-map alignment represents a considerable noise reduction which has biological relevance, as most experimentally annotated TFBSs in these promoters are successfully covered by the MMAs (see main text). Both graphical representations have been produced with the program gff2ps [27].