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Table 2 Extracted switches in the network. Significantly differentially expressed pairs of reactions (p-value ≤ 0.01). The first 20 switches are shown here and described in detail in the text.

From: Using gene expression data and network topology to detect substantial pathways, clusters and switches during oxygen deprivation of Escherichia coli

Rank Up-regulated reactions Metabolites Down-regulated reactions P-value
1 formate hydrogenlyase complex formate formyltetrahydrofolate deformylase 4.67E-14
2 acetaldehyde dehydrogenase acetaldehyde ethanolamine ammonia-lyase 1.25E-12
3 FocA formate FNT transporter formate formyltetrahydrofolate deformylase 5.81E-12
4 formate hydrogenlyase complex formate GTP cyclohydrolase I 1.65E-11
5 3-methyl-2-oxobutanoate hydroxymethyltransferase 2-dehydropantoate 2-dehydropantoate reductase 2.33E-11
6 serine hydroxymethyltransferase tetrahydrofolate, 5,10-methylene-THF, glycine gcv system 6.69E-09
7 serine hydroxymethyltransferase glycine glycine dehydrogenase (decarboxylating) 2.07E-08
8 formate dehydrogenase formate formyltetrahydrofolate deformylase 1.30E-07
9 2-keto-4-hydroxyglutarate aldolase glyoxylate glyoxylate reductase B,glyoxylate reductase 1.74E-07
10 fumarate reductase fumarate 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase 2.00E-07
11 fumarate reductase fumarate adenylosuccinate lyase 2.00E-07
12 CTP synthetase UTP galactose-1-phosphate uridylyltransferase 3.16E-07
13 gluconokinase gluconate 2-ketoaldonate reductase 1.36E-05
14 phosphoenolpyruvate carboxylase oxaloacetate aspartate transaminase 2.00E-05
15 FocA formate FNT transporter formate GTP cyclohydrolase I 3.35E-05
16 BrnQ branched chain amino acid LIVCS transporters L-isoleucine branched chain amino acids ABC transporters 3.78E-05
17 BrnQ branched chain amino acid LIVCS transporters L-leucine branched chain amino acids ABC transporters 3.78E-05
18 BrnQ branched chain amino acid LIVCS transporters L-valine branched chain amino acids ABC transporters 3.78E-05
19 3-hydroxy acid dehydrogenase L-serine phosphoserine phosphatase 4.33E-05
20 phosphatidylglycerophosphate synthase a CDP-diacylglycerol, CMP CDP-diacylglycerol pyrophosphatase 4.78E-05