All predictions within citrate synthase, as discussed in the text, are shown in spacefill. Note that they all cluster within the active site region. Coenzyme-A and the citrate substrate are shown in purple and magenta, respectively. The two correctly predicted catalytic residues are shown in red; the unpredicted catalytic residue (His262) is shown in orange. The image on the left, which is rotated 180 degrees from the one on the right, is centered on Asp312 whereas the image on the right is centered on His223. Unfiltered predictions are colored cyan. Except for Lys219, the remaining accessibility and residue identity filtered predictions are colored yellow and blue, respectively. Lys219, which is predicted by both filtering schemes, is colored green (yellow + blue = green).