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Table 2 Comparison between the results of our computational approach and seed regions of known miRNAs.

From: Identification of candidate regulatory sequences in mammalian 3' UTRs by statistical analysis of oligonucleotide distributions

Method 7-mers identified corresponding to known miRNA expected by chance P-value
CO 465 74 28.9 5.0 · 10-14
SA 214 41 13.3 7.9 · 10-11
CSA 113 19 7.01 6.3 · 10-5
COCSA 59 14 3.66 1.1 · 10-5
CO SA 601 94 37.3 4.8 · 10-17
  1. The rows indicate the computational methods as described in the text: CO = conserved overrepresentation; SA = strand asymmetry; CSA = conserved strand asymmetry (oligos displaying strand asymmetry in both human and mouse); COCSA oligos identified by both CO and CSA;COSA: oligos identified by either conserved overrepresentation or strand asymmetry (human) or both. The columns are (1) Number of oligos identified computationally; (2) Number of these matching the seed region of known human miRNAs; (3) number of such matches expected by chance; (4) number of different known human miRNAs putatively binding the oligos (many 7-oligos occur in the seed region of more than one miRNA) (5) P-value from exact Fisher test, taking into account that there are 16384 possible 7-mers 1017 of which are seed regions of known miRNAs.