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Table 1 Rate constants and initial populations in system (Al) used to maintain the time scale separation at ~O(104) as the population X0 increases.

From: A hybrid multiscale Monte Carlo algorithm (HyMSMC) to cope with disparity in time scales and species populations in intracellular networks

Initial Population XA = XB = XC = X0/3 Fast Network k1 = k-1 (s-1) Slow Network k2 = k-2(s-1)
5 104 1.0
50 103 10-1
500 102 10-2
5000 10 10-3
50000 1.0 10-4
  1. The rate constants have been proportionally scaled down with increasing population to maintain the reaction propensities approximately constant.