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Figure 6 | BMC Bioinformatics

Figure 6

From: A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways

Figure 6

Effect of SCD activators clofibrate and ciprofibrate on LDH release in the palmitate cultures. Clofibrate and ciprofibrate are known to transcriptionally increase the activity of SCD. Palm: treated with 0.7 mM palmitate for 48 hours, Palm+clofibrate: treated with 50 μM clofibrate and 0.7 mM palmitate, Palm+ciprofibrate: treated with 50 μM ciprofibrate and 0.7 mM palmitate. 6 hours pretreatment followed by 48 hours co-supplementation of 50 μM of clofibrate or ciprofibrate significantly decrease LDH release in the palmitate culture, P < 0.01 (t-test). Data expressed as average +/- SD from three independent experiments, * significantly lower than in control, p < 0.01 by t-test. H: control, P: palmitate treatment, O: oleate treatment, P+O: palmitate and oleate co-supplementation.

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BMC Bioinformatics

ISSN: 1471-2105

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