Table 1 Functional groups of genes related to LDH release, selected by GA/PLS
Functional Category | Accession Number | Gene name | Frequency |
|---|---|---|---|
Oxidative Stress | |||
AA418907 | (gC) cytochrome P450, polypeptide 1 (CYP1A1) | 12 | |
H93482 | (g) glutamate-cysteine ligase, catalytic subunit | 11 | |
AA111999 | (gC) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 | 10 | |
T73468 | (gC) glutathione S-transferase A2 (GSTA2) | 10 | |
T73294 | (gC) P450 (cytochrome) oxidoreductase (POR) | 10 | |
H99813 | (gC) glutathione S-transferase theta 1 (GSTT1) | 10 | |
AA460251 | (gC) NADH dehydrogenase (ubiquinone) 1 | 9 | |
AA046701 | (gC) ATP synthase, H+ transporting, subunit c | 8 | |
AA291163 | (gC) glutaredoxin (thioltransferase) (GLRX) | 8 | |
AA777289 | (gC) glutathione reductase (GSR) | 8 | |
R63065 | (gC) glutathione S-transferase M3 | 8 | |
AA664180 | (gC) glutathione peroxidase 3 (plasma) (GPX3) | 7 | |
H53340 | (gC) metallothionein 1G (MT1G) | 7 | |
N72263 | (gC) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 | 7 | |
AA865265 | (gC) cytochrome c (HCS) | 7 | |
N21576 | (gC) cytochrome P450, subfamily XXIV (CYP24) | 7 | |
AA022627 | (gC) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 | 7 | |
T72259 | (gK) cytochrome P450, polypeptide 7 (CYP2A7) | 7 | |
AA281549 | (gM) holocytochrome c synthase (HCCS) | 7 | |
AA490938 | (gM) NAD(P)H dehydrogenase, quinone 2 (NQO2), mRNA | 7 | |
W73474 | (gC) microsomal glutathione S-transferase 2 (MGST2) | 7 | |
T98002 | (gC) cytochrome P450, subfamily IVF, polypeptide 12 (CYP4F12) | 7 | |
TCA Cycle | |||
AA679907 | (gC) isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) | 12 | |
N67639 | (gC) citrate synthase (CS) | 8 | |
AA234519 | (gC) succinate-CoA ligase, GDP-forming, beta subunit | 7 | |
Transcription factor | |||
AA406269 | (g) nuclear factor I/X (CCAAT-binding transcription factor) (NFIX) | 12 | |
AA24743 | (gC) zinc finger protein 36, C3H type-like 1 (ZFP36L1) | 9 | |
AA608536 | (gC) inhibitor of kappa light polypeptide gene enhancer in B-cells | 7 | |
TNF- Signal | |||
AA134814 | (gC) TRAF family member-associated NFκβ activator (TANK) | 9 | |
W72329 | (gC) lymphotoxin alpha (TNF- superfamily, member 1) (LTA) | 9 | |
AA486789 | (gC) Fas (TNF-RSF6) associated factor 1 (FAF1) | 8 | |
AA443577 | (gC) tumor necrosis factor (ligand) superfamily, member 13 (TNF-SF13) | 8 | |
AA625666 | (gC) LPS-induced TNF-alpha factor (PIG7) | 8 | |
AA433944 | (gC) Fas (TNF-RSF6)-associated via death domain (FADD) | 7 | |
AA476272 | (g) tumor necrosis factor, alpha-induced protein 3 (TNF-AIP3) | 7 | |
H98636 | (gK) tumor necrosis factor receptor superfamily, member 5 (TNF-RSF5) | 7 | |
N50859 | (gC) TNF-AIP3 interacting protein 2 (TNIP2) | 7 | |
T64483 | (gC) TNF-AIP3 interacting protein 1 (TNIP1) | 7 | |
R71691 | (gC) TNF- receptor-associated factor 1 (TRAF1) | 7 | |
AA456314 | (gC) tumor necrosis factor, alpha-induced protein 1 (TNF-AIP1) | 7 | |
AA778663 | (gC) tumor necrosis factor (ligand) superfamily, member 9 (TNF-SF9) | 7 | |
Signal pathways | |||
R32848 | (gC) S100 calcium binding protein P (S100P) | 12 | |
T62952 | (gC) protein phosphatase 4, regulatory subunit 1 (PPP4R1) | 10 | |
AA019459 | (gC) protein tyrosine kinase 9 (PTK9) | 10 | |
R72296 | (gC) protein phosphatase 1, regulatory (inhibitor) subunit 15B | 10 | |
AA598996 | (gM) solute carrier family 38, member 2 (SLC38A2) | 10 | |
AA496810 | (gM) protein kinase C substrate 80K-H (PRKCSH) | 10 | |
AA454810 | (g) tumor-associated calcium signal transducer 2 (TACSTD2) | 10 | |
AA453754 | (gC) serine/threonine kinase 17a (apoptosis-inducing) (STK17A) | 9 | |
AA488413 | (gC) MAP kinase-interacting serine/threonine kinase 2 (MKNK2) | 9 | |
N47552 | (gC) mitogen-activated protein kinase 6 | 9 | |
W68184 | (gC) phospholipase A2, group IVB (cytosolic) | 9 | |
AA233185 | (gC) insulin-like growth factor binding protein 1 (IGFBP1) | 9 | |
R45941 | (gM) protein tyrosine phosphatase, receptor type, N (PTPRN) | 8 | |
W79920 | (gN) G protein-coupled receptor 87 (GPR87) | 8 | |
H01164 | (gC) serine/threonine kinase 17a (apoptosis-inducing) (STK17A) | 8 | |
AA45819 | (gC) mitogen-activated protein kinase 3 | 8 | |
AA678095 | (gM) G protein-coupled receptor 48 (GPR48) | 8 | |
AA487028 | (gM) protein phosphatase 1, regulatory (inhibitor) subunit 12A (PPP1R12A) | 8 | |
H90855 | (gC) mitogen-activated protein kinase kinase kinase 7 | 8 | |
AA485347 | (gM) protein phosphatase 1, regulatory (inhibitor) subunit 11 (PPP1R11) | 8 | |
AA789328 | (gC) cyclin-dependent kinase (CDC2-like) 10 (CDK10) | 8 | |
W44762 | (gC) potassium inwardly-rectifying channel, subfamily J, member 2 (KCNJ2) | 8 | |
R44740 | (gC) mitogen-activated protein kinase kinase 1 (MAP2K1) | 8 | |
AA047570 | (gM) phospholipase C, delta 4 (PLCD4) | 7 | |
H11054 | (gC) protein kinase C, delta | 7 | |
AA443982 | (gC) protein phosphatase 1, catalytic subunit, alpha isoform (PPP1CA) | 7 | |
AA480906 | (gC) protein kinase C binding protein 1 | 7 | |
AA490473 | (gC) protein phosphatase 2 (formerly 2A), catalytic subunit | 7 | |
AA679208 | (gC) MAP3K7IP1 | 7 | |
R19158 | (gC) serine/threonine kinase 6 (STK6) | 7 | |
R79082 | (gC) protein tyrosine phosphatase, receptor type, K (PTPRK) | 7 | |
R50953 | (gC) MAP4K2 | 7 | |
AA862435 | (gC) G protein-coupled receptor kinase 5 (GPRK5) | 7 | |
AA464590 | (gC) protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2) | 7 | |
Fatty acid metabolism | |||
AA877618 | (gC) fatty acid amide hydrolase (FAAH) | 12 | |
H29215 | (gC) fatty-acid-Coenzyme A ligase, long-chain 3 (FACL3) | 9 | |
T98355 | (gC) long-chain fatty-acyl elongase (LCE) | 7 | |
AA678178 | (gC) fatty acid amide hydrolase | 7 | |
Apoptosis | |||
AA446839 | (gC) BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) | 10 | |
W45688 | (gN) caspase 6, apoptosis-related cysteine protease (CASP6) | 10 | |
AA676836 | (gC) acid sphingomyelinase-like phosphodiesterase (ASM3A) | 9 | |
AA448468 | (gC) caspase 8, apoptosis-related cysteine protease (CASP8) | 8 | |
H80712 | (gC) caspase 10, apoptosis-related cysteine protease (CASP10) | 8 | |
AA496782 | (gF) requiem, apoptosis response zinc finger gene (REQ) | 8 | |
AA165628 | (gC) UDP-glucose ceramide glucosyltransferase | 7 | |
AA630354 | (gC) sphingosine kinase 2 (SPHK2) | 7 | |
AA156940 | (gC) programmed cell death 5 (PDCD5) | 7 | |
AA459381 | (gC) sphingosine-1-phosphate lyase 1 | 7 | |
T57777 | (gC) BCL2-like 13 (apoptosis facilitator) (BCL2L13) | 7 | |
Translation | |||
AA456664 | (gM) eukaryotic translation termination factor 1 (ETF1) | 10 | |
AA027240 | (gC) eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (EIF2S2) | 10 | |
N72715 | (gC) translational inhibitor protein p14.5 (UK114) | 8 | |
AA916914 | (gC) eukaryotic translation initiation factor 3, subunit 10 theta | 8 | |
AA191463 | (gC) eukaryotic translation initiation factor 4 gamma, 3 (EIF4G3) | 7 | |
H92556 | (gC) eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa (EIF2B2) | 8 | |
Mitochondria Related | |||
AA457118 | (gC) translocase of outer mitochondrial membrane 34 (TOMM34) | 10 | |
R86713 | (gC) translocase of inner mitochondrial membrane 22 homolog (yeast) (TIMM22) | 9 | |
AA644550 | (gM) translocase of outer mitochondrial membrane 20 | 7 | |