Table 1 Overview of the evaluated normalization methods. The compared normalization methods and their corresponding properties. a The spatial effect is constrained to print-tip based effects. b The method can be extended to support this feature.
From: Orthogonal projections to latent structures as a strategy for microarray data normalization
Method name | Short name | Ratio-based | Spatial | Between-array |
|---|---|---|---|---|
Global median | Median | Yes | No | No |
Global loess | Loess | Yes | No | No |
Print-tip loess | PT-loess | Yes | Yesa | No |
Print-tip loess with Tquantile norm. | PT-loess/Tq | Yes/Yes | Yesa/No | No/Yes |
OLIN | OLIN | Yes | Yes | No |
VSN | VSN | No | Nob | No |
Global loess with ANOVA | ANOVA | Yes/No | No/Yes | No/Yes |
OPLS | OPLS | No | Yes | Yes |