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Table 1 Reactions whose directions have to be reversed to restore connectivity of metabolites using mechanism 1.

From: Optimization based automated curation of metabolic reconstructions

(GapFill) identified reversible reactions in E. coli Corresponding metabolite(s) in E. coli which is (are) fixed Pathway
ADOCBLS rdmbzi, agdpcbi, adocbi, adocbip Cofactor and Prosthetic Group Biosynthesis
HETZK 4mhetz Cofactor and Prosthetic Group Biosynthesis
HMPK1 4ahmmp Cofactor and Prosthetic Group Biosynthesis
SPODM o2- Unassigned
DXYLK dxyl Cofactor and Prosthetic Group Biosynthesis
ACBIPGT adocbi, adocbip, 5prdmbz Cofactor and Prosthetic Group Biosynthesis
PGLYCP 2pglyc Alternate Carbon Metabolism
NNDMBRT 5prdmbz, dmbzid Cofactor and Prosthetic Group Biosynthesis
PEAMNO peamn Alternate Carbon Metabolism
ALDD19x peamn Alternate Carbon Metabolism
CRNt7 crn, gbbtn, ctbt, crncoa*, bbtcoa, ctbtcoa Transport, Extracellular
AP4AH ap4a Nucleotide Salvage Pathways
2DGLCNRy 2dhglcn Alternate Carbon Metabolism
DKGLCNR2x 2dhglcn, 25dkglcn Alternate Carbon Metabolism
BETALDHx betald Unassigned
BETALDHy betald Unassigned
DKGLCNR1 25dkglcn, 2dhglcn Alternate Carbon Metabolism
X5PL3E ap5a, xu5pL, Alternate Carbon Metabolism
DKGLCNR2y 25dkglcn Alternate Carbon Metabolism
DKGLCNR2x 25dkglcn, 2dhglcn Alternate Carbon Metabolism
2DGULRx 2dhguln Alternate Carbon Metabolism
2DGULRy 2dhguln Alternate Carbon Metabolism
GP4GH gp4g Nucleotide Salvage Pathways
DOGULNR 23doguln, 3dhguln Alternate Carbon Metabolism
ADOCBIK adocbi Cofactor and Prosthetic Group Biosynthesis
KG6PDC 3dgulnp, 3dhguln Alternate Carbon Metabolism
RZ5PP dmbzid Cofactor and Prosthetic Group Biosynthesis
GPDDA5 g3pi Cell Envelope Biosynthesis
GPDDA3 g3ps Cell Envelope Biosynthesis
  1. The reactions in bold have support in the EcoCyc database. The pathways in which these reactions are present and the metabolites whose production they enable are as shown. The metabolites shown in bold are fixed by a combination of mechanisms 1 and 2.