Figure 1
From: Gene network interconnectedness and the generalized topological overlap measure
Proportions of essential proteins among the S proteins that are most highly interconnected with a given essential hub protein in the Drosophila protein-protein interaction network. For a given neighborhood size S (x-axis) we averaged the results over 30 essential hub proteins (y-axis). The black horizontal line (GTOM0) represents the average proportion of essential proteins among the directly linked neighbors (adjacency = 1) of an essential hub protein.