Figure 1
From: Gene network interconnectedness and the generalized topological overlap measure
![Figure 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1471-2105-8-22/MediaObjects/12859_2006_Article_1394_Fig1_HTML.jpg)
Proportions of essential proteins among the S proteins that are most highly interconnected with a given essential hub protein in the Drosophila protein-protein interaction network. For a given neighborhood size S (x-axis) we averaged the results over 30 essential hub proteins (y-axis). The black horizontal line (GTOM0) represents the average proportion of essential proteins among the directly linked neighbors (adjacency = 1) of an essential hub protein.